Krueppel C2H2-type zinc-finger

Definition

The Krueppel C2H2-type zinc-finger protein family is characterized by a conserved zinc-finger domain that mediates DNA binding and is involved in transcriptional regulation. Members of this family function predominantly as transcriptional repressors or activators, influencing various biological processes including development, differentiation, apoptosis, and metabolism. Some proteins within this family are known to interact with chromatin-modifying proteins, such as SETDB1 and TRIM28/KAP1, to establish repressive chromatin states. Others are involved in maintaining genomic imprints through DNA methylation. The family also includes proteins that regulate lipid metabolism, neuron death, and retrotransposon repression in embryonic stem cells. The diversity of functions reflects the broad role of Krueppel C2H2-type zinc-finger proteins in gene expression and cellular homeostasis.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• KRBOX1
• KRBOX4
• KRBOX5
• ZNF688
• ZNF788P