Seroatlas · Human Serome Atlas

KRBOX1

KRAB domain-containing protein 1

Also known as: ENSG00000290317, KRBX1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
C9JBD0
Gene
KRBOX1
Ensembl
ENSG00000240747
Chromosome
3
Canonical length
128 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Predicted to be involved in regulation of DNA-templated transcription. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

128 residues, UniProt reviewed canonical sequence.

>C9JBD0|KRBOX1
     1  MMTAVSLTTR PQESVAFEDV AVYFTTKEWA IMVPAERALY RDVMLENYEA VAFVVPPTSK
    61  PALVSHLEQG KESCFTQPQG VLSRNDWRAG WIGYLELRRY TYLAKAVLRR IVSKIFRNRQ
   121  CWEDRRKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRBOX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
192 nTPM

Expression across tissuesHPA

Tissue

  • testis: 192 nTPM
  • ovary: 9.7 nTPM
  • epididymis: 8 nTPM
  • cervix: 7.8 nTPM
  • endometrium: 5.9 nTPM
  • blood vessel: 5.7 nTPM

Single-cell type

  • late primary spermatocytes: 5.6 nCPM
  • early primary spermatocytes: 1.2 nCPM
  • differentiating spermatogonia: 0.9 nCPM
  • ependymal cells: 0.8 nCPM
  • granulosa cells: 0.8 nCPM
  • oligodendrocyte progenitor cells: 0.5 nCPM

Immune cell

  • NK-cell: 4 nTPM
  • plasmacytoid DC: 1 nTPM
  • eosinophil: 0.7 nTPM
  • non-classical monocyte: 0.7 nTPM
  • naive CD8 T-cell: 0.4 nTPM
  • classical monocyte: 0.3 nTPM

Brain region

  • white matter: 1.8 nTPM
  • cerebral cortex: 1.5 nTPM
  • hypothalamus: 1.4 nTPM
  • medulla oblongata: 1.3 nTPM
  • basal ganglia: 1.1 nTPM
  • cerebellum: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.52
gnomAD pLI
0.02
gnomAD missense Z
0.73
DepMap mean gene effect
-0.02
DepMap dependency class
selective

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRBOX1 as an antibody target. Whether an autoantibody or antibody against KRBOX1 could matter depends on whether native KRBOX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRBOX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRBOX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KRBOX1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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