Seroatlas · Human Serome Atlas

KRBOX4

KRAB domain-containing protein 4

Also known as: FLJ20344, KRBX4_HUMAN, ZNF673

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5JUW0
Gene
KRBOX4
Ensembl
ENSG00000147121
Chromosome
X
Canonical length
171 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This encodes a zinc finger protein with an N-terminal KRAB (Kruppel-associated) domain found in transcriptional repressors. This gene is located in a region of the X chromosome thought to be involved in nonsyndromic X-linked cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

171 residues, UniProt reviewed canonical sequence.

>Q5JUW0|KRBOX4
     1  MAMSQESLTF KDVFVDFTLE EWQQLDSAQK NLYRDVMLEN YSHLVSVGYL VAKPDVIFRL
    61  GPGEESWMAD GGTPVRTCAG EDRPEVWQVD EQIDHYKESQ DKLPWQAAFI GKETLKDESG
   121  QESRTCRKSI YLSTEFDSVR QRLPKYYSWE KAFKTSFKLS WSKWKLCKKE R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRBOX4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 21 nTPM
  • spleen: 19 nTPM
  • cerebellum: 18 nTPM
  • ovary: 18 nTPM
  • endometrium: 17 nTPM
  • liver: 17 nTPM

Single-cell type

  • bergmann glia: 92 nCPM
  • oligodendrocyte progenitor cells: 68 nCPM
  • choroid plexus epithelial cells: 68 nCPM
  • oligodendrocytes: 66 nCPM
  • microglia: 62 nCPM
  • astrocytes: 55 nCPM

Immune cell

  • naive B-cell: 19 nTPM
  • basophil: 18 nTPM
  • naive CD4 T-cell: 17 nTPM
  • NK-cell: 16 nTPM
  • eosinophil: 16 nTPM
  • memory CD4 T-cell: 14 nTPM

Brain region

  • hypothalamus: 44 nTPM
  • basal ganglia: 36 nTPM
  • choroid plexus: 36 nTPM
  • cerebral cortex: 35 nTPM
  • white matter: 35 nTPM
  • pons: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.88
gnomAD pLI
0.65
gnomAD missense Z
0.26

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRBOX4 as an antibody target. Whether an autoantibody or antibody against KRBOX4 could matter depends on whether native KRBOX4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRBOX4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRBOX4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KRBOX4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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