Seroatlas · Human Serome Atlas

ZNF688

Zinc finger protein 688

Also known as: ZN688_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C7X2
Gene: ZNF688
Ensembl: ENSG00000229809
Chromosome: 16
Canonical length: 276 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cell Junctions

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

276 residues, UniProt reviewed canonical sequence.

>P0C7X2|ZNF688
     1  MAPPPAPLLA PRPGETRPGC RKPGTVSFAD VAVYFSPEEW GCLRPAQRAL YRDVMQETYG
    61  HLGALGFPGP KPALISWMEQ ESEAWSPAAQ DPEKGERLGG ARRGDVPNRK EEEPEEVPRA
   121  KGPRKAPVKE SPEVLVERNP DPAISVAPAR AQPPKNAAWD PTTGAQPPAP IPSMDAQAGQ
   181  RRHVCTDCGR RFTYPSLLVS HRRMHSGERP FPCPECGMRF KRKFAVEAHQ WIHRSCSGGR
   241  RGRRPGIRAV PRAPVRGDRD PPVLFRHYPD IFEECG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF688 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

testis: 41 nTPM
skeletal muscle: 23 nTPM
liver: 20 nTPM
amygdala: 19 nTPM
colon: 19 nTPM
pancreas: 18 nTPM

Single-cell type

late spermatids: 967 nCPM
early spermatids: 154 nCPM
late primary spermatocytes: 152 nCPM
fallopian tube ciliated cells: 104 nCPM
respiratory ciliated cells: 91 nCPM
enterocytes: 54 nCPM

Immune cell

NK-cell: 21 nTPM
basophil: 12 nTPM
T-reg: 11 nTPM
eosinophil: 11 nTPM
naive B-cell: 7.6 nTPM
plasmacytoid DC: 7.4 nTPM

Brain region

white matter: 23 nTPM
cerebellum: 22 nTPM
basal ganglia: 20 nTPM
thalamus: 20 nTPM
cerebral cortex: 20 nTPM
midbrain: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0
gnomAD missense Z: 0.85
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF688 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF688 as an antibody target. Whether an autoantibody or antibody against ZNF688 could matter depends on whether native ZNF688 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF688 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF688 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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