Seroatlas · Human Serome Atlas

KRBOX5

KRAB domain-containing protein 5

Also known as: KRBX5_HUMAN, ZNF720

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z2F6
Gene
KRBOX5
Ensembl
ENSG00000197302
Chromosome
16
Canonical length
126 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

126 residues, UniProt reviewed canonical sequence.

>Q7Z2F6|KRBOX5
     1  MGLLTFRDVA IEFSREEWEH LDSDQKLLYG DVMLENYGNL VSLGLAVSKP DLITFLEQRK
    61  EPWNVKSAET VAIQPDIFSH DTQGLLRKKL IEASFQKVIL DGYGSCGPQN LNLRKEWESE
   121  GKIILW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRBOX5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
9.2 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 9.2 nTPM
  • spleen: 7.9 nTPM
  • skin: 7.8 nTPM
  • appendix: 7.4 nTPM
  • retina: 7.3 nTPM
  • tonsil: 7.3 nTPM

Single-cell type

  • syncytiotrophoblasts: 102 nCPM
  • pituicytes/fscs: 75 nCPM
  • epididymal principal cells: 65 nCPM
  • choroid plexus epithelial cells: 57 nCPM
  • esophageal apical cells: 56 nCPM
  • thymocytes: 56 nCPM

Immune cell

  • eosinophil: 21 nTPM
  • memory B-cell: 14 nTPM
  • basophil: 14 nTPM
  • naive B-cell: 13 nTPM
  • NK-cell: 12 nTPM
  • T-reg: 12 nTPM

Brain region

  • cerebellum: 18 nTPM
  • choroid plexus: 13 nTPM
  • medulla oblongata: 12 nTPM
  • pons: 12 nTPM
  • midbrain: 11 nTPM
  • spinal cord: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0.22
DepMap mean gene effect
-0.22
DepMap dependency class
selective

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRBOX5 as an antibody target. Whether an autoantibody or antibody against KRBOX5 could matter depends on whether native KRBOX5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRBOX5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRBOX5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KRBOX5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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