Lysophospholipid acyltransferase 7/Porcupine-like

Definition

This entry represents a group of eukaryotic proteins, including human Lysophospholipid acyltransferase 7 (LPLAT 7) and Protein-serine O-palmitoleoyltransferase porcupine (PORCN). LPLAT 7 catalyses the transfer of an acyl group from an acyl-CoA to a lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) leading to the production of a phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) and participates in the reacylation step of the phospholipid remodelling pathway also known as the Lands cycle [[cite:PMID:18772128], [cite:PMID:18094042]]. Alterations on its expression are associated to brain developmental disorders, fatty liver disease and hepatocellular and renal cancers. Its structure is mainly α-helical, with 11 transmembrane (TM) helical segments linked by short intervening helices (IH) and loops PMID:37316513. PORCN acts as a key regulator of the Wnt signalling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins PMID:24292069. This protein shows a similar structural configuration to LPLAT7, with 11 TMs, 6 (IH) and 2 β-strands PMID:35831507.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• LPCAT3
• MBOAT1
• MBOAT2
• MBOAT4
• MBOAT7
• PORCN