Seroatlas · Human Serome Atlas

MBOAT2

Membrane-bound glycerophospholipid O-acyltransferase 2

Also known as: FLJ14415, FLJ90298, LPLAT13, MBOA2_HUMAN, OACT2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZWT7
Gene
MBOAT2
Ensembl
ENSG00000143797
Chromosome
2
Canonical length
520 aa
Protein class
Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location
Vesicles

OverviewNCBI Gene

Enables 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphoethanolamine O-acyltransferase activity; and 1-acylglycerophosphoserine O-acyltransferase activity. Involved in phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; and phosphatidylserine acyl-chain remodeling. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

520 residues, UniProt reviewed canonical sequence.

>Q6ZWT7|MBOAT2
     1  MATTSTTGST LLQPLSNAVQ LPIDQVNFVV CQLFALLAAI WFRTYLHSSK TSSFIRHVVA
    61  TLLGLYLALF CFGWYALHFL VQSGISYCIM IIIGVENMHN YCFVFALGYL TVCQVTRVYI
   121  FDYGQYSADF SGPMMIITQK ITSLACEIHD GMFRKDEELT SSQRDLAVRR MPSLLEYLSY
   181  NCNFMGILAG PLCSYKDYIT FIEGRSYHIT QSGENGKEET QYERTEPSPN TAVVQKLLVC
   241  GLSLLFHLTI CTTLPVEYNI DEHFQATASW PTKIIYLYIS LLAARPKYYF AWTLADAINN
   301  AAGFGFRGYD ENGAARWDLI SNLRIQQIEM STSFKMFLDN WNIQTALWLK RVCYERTSFS
   361  PTIQTFILSA IWHGVYPGYY LTFLTGVLMT LAARAMRNNF RHYFIEPSQL KLFYDVITWI
   421  VTQVAISYTV VPFVLLSIKP SLTFYSSWYY CLHILGILVL LLLPVKKTQR RKNTHENIQL
   481  SQSKKFDEGE NSLGQNSFST TNNVCNQNQE IASRHSSLKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MBOAT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
9
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 28 nTPM
  • bone marrow: 25 nTPM
  • choroid plexus: 21 nTPM
  • spinal cord: 19 nTPM
  • cerebral cortex: 17 nTPM
  • midbrain: 16 nTPM

Single-cell type

  • esophageal apical cells: 1,372 nCPM
  • salivary duct cells: 713 nCPM
  • neutrophil progenitors: 667 nCPM
  • neutrophils: 645 nCPM
  • erythrocyte progenitors: 619 nCPM
  • esophageal suprabasal cells: 523 nCPM

Immune cell

  • basophil: 4.7 nTPM
  • neutrophil: 4 nTPM
  • eosinophil: 1.7 nTPM
  • classical monocyte: 0.4 nTPM
  • myeloid DC: 0.4 nTPM
  • total PBMC: 0.2 nTPM

Brain region

  • white matter: 57 nTPM
  • choroid plexus: 53 nTPM
  • basal ganglia: 46 nTPM
  • midbrain: 45 nTPM
  • thalamus: 44 nTPM
  • hypothalamus: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.52
gnomAD missense Z
1.7
DepMap mean gene effect
0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MBOAT2 as an antibody target. Whether an autoantibody or antibody against MBOAT2 could matter depends on whether native MBOAT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MBOAT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MBOAT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MBOAT2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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