Seroatlas · Human Serome Atlas

MBOAT4

Membrane-bound ghrelin O-acyltransferase MBOAT4

Also known as: FKSG89, GOAT, MBOA4_HUMAN, OACT4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96T53
Gene
MBOAT4
Ensembl
ENSG00000177669
Chromosome
8
Canonical length
435 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Golgi apparatus

OverviewNCBI Gene

Enables acyltransferase activity, transferring groups other than amino-acyl groups. Involved in peptidyl-serine octanoylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

435 residues, UniProt reviewed canonical sequence.

>Q96T53|MBOAT4
     1  MEWLWLFFLH PISFYQGAAF PFALLFNYLC IMDSFSTRAR YLFLLTGGGA LAVAAMGSYA
    61  VLVFTPAVCA VALLCSLAPQ QVHRWTFCFQ MSWQTLCHLG LHYTEYYLHE PPSVRFCITL
   121  SSLMLLTQRV TSLSLDICEG KVKAASGGFR SRSSLSEHVC KALPYFSYLL FFPALLGGSL
   181  CSFQRFQARV QGSSALHPRH SFWALSWRGL QILGLECLNV AVSRVVDAGA GLTDCQQFEC
   241  IYVVWTTAGL FKLTYYSHWI LDDSLLHAAG FGPELGQSPG EEGYVPDADI WTLERTHRIS
   301  VFSRKWNQST ARWLRRLVFQ HSRAWPLLQT FAFSAWWHGL HPGQVFGFVC WAVMVEADYL
   361  IHSFANEFIR SWPMRLFYRT LTWAHTQLII AYIMLAVEVR SLSSLWLLCN SYNSVFPMVY
   421  CILLLLLAKR KHKCN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MBOAT4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
3.5 nTPM

Expression across tissuesHPA

Tissue

  • stomach: 3.5 nTPM
  • pancreas: 3.3 nTPM
  • fallopian tube: 1.6 nTPM
  • gallbladder: 0.9 nTPM
  • adrenal gland: 0.5 nTPM
  • bone marrow: 0.5 nTPM

Single-cell type

  • neuroendocrine cells: 42 nCPM
  • pancreatic islet cells: 41 nCPM
  • cholangiocytes: 35 nCPM
  • epicardial cells: 18 nCPM
  • t-cells: 8 nCPM
  • pancreatic duct cells: 6.8 nCPM

Immune cell

  • naive CD8 T-cell: 1.2 nTPM
  • naive B-cell: 1 nTPM
  • neutrophil: 0.8 nTPM
  • NK-cell: 0.8 nTPM
  • eosinophil: 0.7 nTPM
  • MAIT T-cell: 0.7 nTPM

Brain region

  • cerebral cortex: 0.8 nTPM
  • midbrain: 0.8 nTPM
  • amygdala: 0.7 nTPM
  • hippocampal formation: 0.7 nTPM
  • hypothalamus: 0.7 nTPM
  • white matter: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.15
gnomAD pLI
0
gnomAD missense Z
1.51
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MBOAT4 as an antibody target. Whether an autoantibody or antibody against MBOAT4 could matter depends on whether native MBOAT4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MBOAT4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MBOAT4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MBOAT4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...