Seroatlas · Human Serome Atlas

MBOAT1

Membrane-bound glycerophospholipid O-acyltransferase 1

Also known as: dJ434O11.1, LPEAT1, LPLAT14, MBOA1_HUMAN, MGC44669, OACT1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZNC8
Gene
MBOAT1
Ensembl
ENSG00000172197
Chromosome
6
Canonical length
495 aa
Protein class
Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene belongs to the membrane-bound O-acetyltransferase superfamily. The encoded transmembrane protein is an enzyme that transfers organic compounds, preferably from oleoyl-CoA, to hydroxyl groups of protein targets in membranes. A translocation disrupting this gene may be associated with brachydactyly syndactyly syndrome. Alternately spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

495 residues, UniProt reviewed canonical sequence.

>Q6ZNC8|MBOAT1
     1  MAAEPQPSSL SYRTTGSTYL HPLSELLGIP LDQVNFVVCQ LVALFAAFWF RIYLRPGTTS
    61  SDVRHAVATI FGIYFVIFCF GWYSVHLFVL VLMCYAIMVT ASVSNIHRYS FFVAMGYLTI
   121  CHISRIYIFH YGILTTDFSG PLMIVTQKIT TLAFQVHDGL GRRAEDLSAE QHRLAIKVKP
   181  SFLEYLSYLL NFMSVIAGPC NNFKDYIAFI EGKHIHMKLL EVNWKRKGFH SLPEPSPTGA
   241  VIHKLGITLV SLLLFLTLTK TFPVTCLVDD WFVHKASFPA RLCYLYVVMQ ASKPKYYFAW
   301  TLADAVNNAA GFGFSGVDKN GNFCWDLLSN LNIWKIETAT SFKMYLENWN IQTATWLKCV
   361  CYQRVPWYPT VLTFILSALW HGVYPGYYFT FLTGILVTLA ARAVRNNYRH YFLSSRALKA
   421  VYDAGTWAVT QLAVSYTVAP FVMLAVEPTI SLYKSMYFYL HIISLLIILF LPMKPQAHTQ
   481  RRPQTLNSIN KRKTD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MBOAT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
9
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 21 nTPM
  • rectum: 18 nTPM
  • colon: 17 nTPM
  • small intestine: 15 nTPM
  • stomach: 14 nTPM
  • cervix: 14 nTPM

Single-cell type

  • salivary ionocytes: 191 nCPM
  • renal collecting duct intercalated cells: 180 nCPM
  • respiratory deuterosomal cells: 170 nCPM
  • neutrophils: 162 nCPM
  • foveolar cells: 132 nCPM
  • salivary duct cells: 126 nCPM

Immune cell

  • eosinophil: 68 nTPM
  • non-classical monocyte: 42 nTPM
  • basophil: 41 nTPM
  • neutrophil: 34 nTPM
  • intermediate monocyte: 34 nTPM
  • classical monocyte: 28 nTPM

Brain region

  • white matter: 18 nTPM
  • medulla oblongata: 15 nTPM
  • pons: 10 nTPM
  • cerebellum: 9 nTPM
  • spinal cord: 8.9 nTPM
  • thalamus: 7.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
-0.03
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MBOAT1 as an antibody target. Whether an autoantibody or antibody against MBOAT1 could matter depends on whether native MBOAT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MBOAT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MBOAT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MBOAT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...