Seroatlas · Human Serome Atlas

LPCAT3

Lysophospholipid acyltransferase 5

Also known as: C3F, LPLAT12, MBOA5_HUMAN, MBOAT5, nessy, OACT5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6P1A2
Gene
LPCAT3
Ensembl
ENSG00000111684
Chromosome
12
Canonical length
487 aa
Protein class
Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphoethanolamine O-acyltransferase activity; and 1-acylglycerophosphoserine O-acyltransferase activity. Involved in phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; and phosphatidylserine acyl-chain remodeling. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

487 residues, UniProt reviewed canonical sequence.

>Q6P1A2|LPCAT3
     1  MASSAEGDEG TVVALAGVLQ SGFQELSLNK LATSLGASEQ ALRLIISIFL GYPFALFYRH
    61  YLFYKETYLI HLFHTFTGLS IAYFNFGNQL YHSLLCIVLQ FLILRLMGRT ITAVLTTFCF
   121  QMAYLLAGYY YTATGNYDIK WTMPHCVLTL KLIGLAVDYF DGGKDQNSLS SEQQKYAIRG
   181  VPSLLEVAGF SYFYGAFLVG PQFSMNHYMK LVQGELIDIP GKIPNSIIPA LKRLSLGLFY
   241  LVGYTLLSPH ITEDYLLTED YDNHPFWFRC MYMLIWGKFV LYKYVTCWLV TEGVCILTGL
   301  GFNGFEEKGK AKWDACANMK VWLFETNPRF TGTIASFNIN TNAWVARYIF KRLKFLGNKE
   361  LSQGLSLLFL ALWHGLHSGY LVCFQMEFLI VIVERQAARL IQESPTLSKL AAITVLQPFY
   421  YLVQQTIHWL FMGYSMTAFC LFTWDKWLKV YKSIYFLGHI FFLSLLFILP YIHKAMVPRK
   481  EKLKKME

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LPCAT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
9
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
116 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 116 nTPM
  • liver: 104 nTPM
  • small intestine: 94 nTPM
  • stomach: 56 nTPM
  • tongue: 54 nTPM
  • pancreas: 49 nTPM

Single-cell type

  • myonuclei: 256 nCPM
  • enterocytes: 212 nCPM
  • cytotrophoblasts: 195 nCPM
  • erythrocyte progenitors: 169 nCPM
  • epicardial cells: 168 nCPM
  • alveolar cells type 1: 168 nCPM

Immune cell

  • non-classical monocyte: 99 nTPM
  • eosinophil: 91 nTPM
  • intermediate monocyte: 80 nTPM
  • classical monocyte: 56 nTPM
  • neutrophil: 53 nTPM
  • basophil: 45 nTPM

Brain region

  • medulla oblongata: 13 nTPM
  • cerebellum: 13 nTPM
  • choroid plexus: 11 nTPM
  • thalamus: 11 nTPM
  • midbrain: 10 nTPM
  • white matter: 9.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
1
gnomAD missense Z
2.45
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LPCAT3 as an antibody target. Whether an autoantibody or antibody against LPCAT3 could matter depends on whether native LPCAT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LPCAT3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LPCAT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LPCAT3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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