Ion-transport regulator, FXYD motif

Definition

This entry represents the FXYD motif of a family of vertebrate small membrane proteins that are involved in the control of ion transport including Phospholemman (FXYD1) and FXYD domain-containing ion transport regulators FXYD2-8 [[cite:PMID:9169143], [cite:PMID:10950925], [cite:PMID:16288923]]. This motif contains 35 invariant and conserved amino acid residues PMID:16288923. Except for FXYD5, all these proteins are very small and their size range from 58 residues for FXYD2 to 95 for FXYD6. FXYD5 is longer (178 residues) due to a N-terminal extension. They all contain a single transmembrane domain. With the exception of FXYD2, they all seem to have a N-terminal signal peptide.

8 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (8 proteins: gene, accession, name)

• FXYD1
• FXYD2
• FXYD3
• FXYD4
• FXYD5
• FXYD6
• FXYD6P3
• FXYD7