Seroatlas · Human Serome Atlas

FXYD2

Sodium/potassium-transporting ATPase subunit gamma

Also known as: ATNG_HUMAN, ATP1G1, HOMG2, MGC12372

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P54710
Gene
FXYD2
Ensembl
ENSG00000137731
Chromosome
11
Canonical length
66 aa
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Mitochondria

OverviewNCBI Gene

This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.[provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

66 residues, UniProt reviewed canonical sequence.

>P54710|FXYD2
     1  MTGLSMDGGG SPKGDVDPFY YDYETVRNGG LIFAGLAFIV GLLILLSRRF RCGGNKKRRQ
    61  INEDEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FXYD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
3,775 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 3,775 nTPM
  • salivary gland: 785 nTPM
  • pancreas: 577 nTPM
  • gallbladder: 332 nTPM
  • thymus: 70 nTPM
  • liver: 23 nTPM

Single-cell type

  • cholangiocytes: 1,857 nCPM
  • epididymal efferent duct absorptive cells: 1,011 nCPM
  • pancreatic duct cells: 207 nCPM
  • epididymal clear cells: 165 nCPM
  • distal convoluted tubule cells: 87 nCPM
  • loop of henle epithelial cells: 69 nCPM

Immune cell

  • memory CD8 T-cell: 15 nTPM
  • NK-cell: 9.6 nTPM
  • naive CD4 T-cell: 5.1 nTPM
  • naive CD8 T-cell: 4.4 nTPM
  • plasmacytoid DC: 3.8 nTPM
  • total PBMC: 2.1 nTPM

Brain region

  • cerebellum: 4.5 nTPM
  • cerebral cortex: 4.5 nTPM
  • basal ganglia: 3 nTPM
  • white matter: 2.5 nTPM
  • amygdala: 2.3 nTPM
  • hippocampal formation: 2.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FXYD2.

Disease | AllUniProt

Conditions FXYD2 is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 90 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Renal hypomagnesemia 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.2
gnomAD pLI
0.11
gnomAD missense Z
-0.16
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FXYD2 as an antibody target. Whether an autoantibody or antibody against FXYD2 could matter depends on whether native FXYD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FXYD2 is annotated at the cell surface, where native FXYD2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FXYD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FXYD2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...