Seroatlas · Human Serome Atlas

FXYD7

FXYD domain-containing ion transport regulator 7

Also known as: FXYD7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P58549
Gene
FXYD7
Ensembl
ENSG00000221946
Chromosome
19
Canonical length
80 aa
Protein class
Predicted membrane proteins, Transporters

OverviewNCBI Gene

This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000]

Canonical amino-acid sequenceUniProt

80 residues, UniProt reviewed canonical sequence.

>P58549|FXYD7
     1  MATPTQTPTK APEEPDPFYY DYNTVQTVGM TLATILFLLG ILIVISKKVK CRKADSRSES
    61  PTCKSCKSEL PSSAPGGGGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FXYD7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
323 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 323 nTPM
  • amygdala: 261 nTPM
  • hippocampal formation: 233 nTPM
  • basal ganglia: 153 nTPM
  • midbrain: 104 nTPM
  • hypothalamus: 100 nTPM

Single-cell type

  • innate lymphoid cells: 59 nCPM
  • brain excitatory neurons: 41 nCPM
  • other brain neurons: 33 nCPM
  • brain inhibitory neurons: 25 nCPM
  • bergmann glia: 20 nCPM
  • t-cells: 16 nCPM

Immune cell

  • NK-cell: 52 nTPM
  • memory CD4 T-cell: 24 nTPM
  • memory B-cell: 19 nTPM
  • memory CD8 T-cell: 17 nTPM
  • gdT-cell: 15 nTPM
  • naive B-cell: 15 nTPM

Brain region

  • cerebral cortex: 352 nTPM
  • white matter: 312 nTPM
  • pons: 206 nTPM
  • medulla oblongata: 193 nTPM
  • hippocampal formation: 192 nTPM
  • amygdala: 182 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.49
gnomAD pLI
0.01
gnomAD missense Z
0.94
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FXYD7 as an antibody target. Whether an autoantibody or antibody against FXYD7 could matter depends on whether native FXYD7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FXYD7 is annotated at the cell surface, where native FXYD7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FXYD7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FXYD7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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