Seroatlas · Human Serome Atlas

PRICKLE4

Prickle-like protein 4

Also known as: C6orf49, DKFZp761H221, OEBT, PRIC4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2TBC4
Gene: PRICKLE4
Ensembl: ENSG00000278224
Chromosome: 6
Canonical length: 344 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitotic spindle,Centriolar satellite

OverviewNCBI Gene

C6ORF49 is a member of the LIM domain protein family (Teufel et al., 2005 [PubMed 15702247]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

344 residues, UniProt reviewed canonical sequence.

>Q2TBC4|PRICKLE4
     1  MSPQGPAVLS LGSLCLDTNQ APNWTGLQTL LQQLPPQDID ERYCLALGEE ERAELQLFCA
    61  RRKQEALGQG VARLVLPKLE GHTCEKCREL LKPGEYGVFA ARAGEQRCWH QPCFACQACG
   121  QALINLIYFY HDGQLYCGRH HAELLRPRCP ACDQLIFSWR CTEAEGQRWH ENHFCCQDCA
   181  GPLGGGRYAL PGGSPCCPSC FENRYSDAGS SWAGALEGQA FLGETGLDRT EGRDQTSVNS
   241  ATLSRTLLAA AGGSSLQTQR GLPGSSPQQE NRPGDKAEAP KGQEQCRLET IRDPKDTPFS
   301  TCSSSSDSEP EGFFLGERLP QSWKTPGSLQ AEDSNASKTH CTMC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRICKLE4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 4.5 nTPM

Expression across tissuesHPA

Tissue

spleen: 4.5 nTPM
esophagus: 3.7 nTPM
cervix: 3.1 nTPM
vagina: 3 nTPM
urinary bladder: 2.9 nTPM
endometrium: 2.7 nTPM

Single-cell type

astrocytes: 1.4 nCPM
ependymal cells: 1.1 nCPM
bergmann glia: 0.9 nCPM
choroid plexus epithelial cells: 0.5 nCPM
oligodendrocyte progenitor cells: 0.5 nCPM
brain excitatory neurons: 0.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 5.2 nTPM
cerebellum: 5.2 nTPM
cerebral cortex: 5.1 nTPM
white matter: 5 nTPM
basal ganglia: 4.9 nTPM
medulla oblongata: 4.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: 0.4
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRICKLE4 as an antibody target. Whether an autoantibody or antibody against PRICKLE4 could matter depends on whether native PRICKLE4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRICKLE4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRICKLE4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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