Seroatlas · Human Serome Atlas

LMCD1

LIM and cysteine-rich domains protein 1

Also known as: LMCD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NZU5
Gene
LMCD1
Ensembl
ENSG00000071282
Chromosome
3
Canonical length
365 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cell Junctions,Cytosol

OverviewNCBI Gene

This gene encodes a member of the LIM-domain family of zinc finger proteins. The encoded protein contains an N-terminal cysteine-rich domain and two C-terminal LIM domains. The presence of LIM domains suggests involvement in protein-protein interactions. The protein may act as a co-regulator of transcription along with other transcription factors. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

365 residues, UniProt reviewed canonical sequence.

>Q9NZU5|LMCD1
     1  MAKVAKDLNP GVKKMSLGQL QSARGVACLG CKGTCSGFEP HSWRKICKSC KCSQEDHCLT
    61  SDLEDDRKIG RLLMDSKYST LTARVKGGDG IRIYKRNRMI MTNPIATGKD PTFDTITYEW
   121  APPGVTQKLG LQYMELIPKE KQPVTGTEGA FYRRRQLMHQ LPIYDQDPSR CRGLLENELK
   181  LMEEFVKQYK SEALGVGEVA LPGQGGLPKE EGKQQEKPEG AETTAATTNG SLSDPSKEVE
   241  YVCELCKGAA PPDSPVVYSD RAGYNKQWHP TCFVCAKCSE PLVDLIYFWK DGAPWCGRHY
   301  CESLRPRCSG CDEIIFAEDY QRVEDLAWHR KHFVCEGCEQ LLSGRAYIVT KGQLLCPTCS
   361  KSKRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LMCD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
537 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 537 nTPM
  • blood vessel: 382 nTPM
  • tongue: 243 nTPM
  • choroid plexus: 135 nTPM
  • lung: 128 nTPM
  • adipose tissue: 124 nTPM

Single-cell type

  • smooth muscle cells: 1,090 nCPM
  • thymic myoid cells: 522 nCPM
  • myonuclei: 489 nCPM
  • decidual stromal cells: 480 nCPM
  • hepatic stellate cells: 458 nCPM
  • vascular endothelial cells: 279 nCPM

Immune cell

  • T-reg: 21 nTPM
  • myeloid DC: 3.3 nTPM
  • memory CD4 T-cell: 2.9 nTPM
  • memory B-cell: 2 nTPM
  • plasmacytoid DC: 1 nTPM
  • memory CD8 T-cell: 0.6 nTPM

Brain region

  • choroid plexus: 72 nTPM
  • white matter: 22 nTPM
  • medulla oblongata: 21 nTPM
  • hippocampal formation: 20 nTPM
  • cerebellum: 20 nTPM
  • spinal cord: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0
gnomAD missense Z
0.66
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LMCD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LMCD1 as an antibody target. Whether an autoantibody or antibody against LMCD1 could matter depends on whether native LMCD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LMCD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LMCD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LMCD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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