Seroatlas · Human Serome Atlas

CFAP210

Cilia- and flagella- associated protein 210

Also known as: C2orf77, CCDC173, CF210_HUMAN, LOC129881

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q0VFZ6
Gene: CFAP210
Ensembl: ENSG00000154479
Chromosome: 2
Canonical length: 552 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in flagellated sperm motility. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

552 residues, UniProt reviewed canonical sequence.

>Q0VFZ6|CFAP210
     1  MDTSSEMLVR FGRRCGRAKE STEIRNSEED QVLYLPLLPS KVDLQQVTII PHDEWKRIQD
    61  SLDRLTREAA CLRAERKAKK EMHLRSQEVV KHWTNTYAGM KEQKLEAKKK RDEEIEAERQ
   121  ILDLEEEIYK QGKRKKAIEN AKQYQFYQTE RVKNFHSGLL LSRVMKERDA QIEFRKSKIK
   181  SDKKWEEQLK LNIEKAFKEE QEKAEKRHRE RVALAKDHLK QIKEHEEEEE RRKKYEEKDA
   241  EEIKRQNALY EIEMRKKLEK KREEMHESRR RFLEHMQDKH IIKAVEQQQQ EEEDEKMRKF
   301  IKAKKRLIQM GKEKEAETHR LMEKRRERIH NFLSELLKEK LDNEDMIIAR DIAEAEAEWE
   361  KREREKDEKN KAELKTIAEY RAIVMKNKEE EERQRKIEAK EQLLAVMKAD QIFWEHEKEK
   421  KCKADKEHQE VQDAHIQQMA KNKFNAKQAK QAELDYCRLT EALVAEKEKE FQDYAREVIE
   481  LESETTNKYI YPLVKAVQEG PGGGRGPVFV DRGGLRPSYQ ANDVTGVQLP FYNSQGPKYN
   541  FQKSKRRLGF TW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP210 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 75 nTPM

Expression across tissuesHPA

Tissue

testis: 75 nTPM
choroid plexus: 45 nTPM
fallopian tube: 14 nTPM
retina: 6.2 nTPM
hippocampal formation: 4.2 nTPM
hypothalamus: 4.2 nTPM

Single-cell type

late primary spermatocytes: 1,594 nCPM
early spermatids: 855 nCPM
respiratory ciliated cells: 680 nCPM
fallopian tube ciliated cells: 575 nCPM
endometrial ciliated cells: 438 nCPM
ependymal cells: 436 nCPM

Immune cell

basophil: 0.5 nTPM
intermediate monocyte: 0.1 nTPM
MAIT T-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

choroid plexus: 43 nTPM
midbrain: 32 nTPM
medulla oblongata: 27 nTPM
spinal cord: 21 nTPM
white matter: 16 nTPM
hippocampal formation: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

flagellated sperm motility

Cellular components

Protein domainsUniProt · Pfam · InterPro

Trichohyalin-plectin-homology domain
Trichohyalin-plectin-homology domain
Cilia- and flagella- associated protein 210

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP210 as an antibody target. Whether an autoantibody or antibody against CFAP210 could matter depends on whether native CFAP210 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP210 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP210 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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