Seroatlas · Human Serome Atlas

MNS1

Meiosis-specific nuclear structural protein 1

Also known as: FLJ11222, MNS1_HUMAN, SPATA40

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NEH6
Gene
MNS1
Ensembl
ENSG00000138587
Chromosome
15
Canonical length
495 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear speckles,Primary cilium,Basal body,Cytosol,Perinuclear theca,Flagellar centriole,End piece

OverviewNCBI Gene

This gene encodes a protein highly similar to the mouse meiosis-specific nuclear structural 1 protein. The mouse protein was shown to be expressed at the pachytene stage during spermatogenesis and may function as a nuclear skeletal protein to regulate nuclear morphology during meiosis. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

495 residues, UniProt reviewed canonical sequence.

>Q8NEH6|MNS1
     1  MGSKRRNLSC SERHQKLVDE NYCKKLHVQA LKNVNSQIRN QMVQNENDNR VQRKQFLRLL
    61  QNEQFELDME EAIQKAEENK RLKELQLKQE EKLAMELAKL KHESLKDEKM RQQVRENSIE
   121  LRELEKKLKA AYMNKERAAQ IAEKDAIKYE QMKRDAEIAK TMMEEHKRII KEENAAEDKR
   181  NKAKAQYYLD LEKQLEEQEK KKQEAYEQLL KEKLMIDEIV RKIYEEDQLE KQQKLEKMNA
   241  MRRYIEEFQK EQALWRKKKR EEMEEENRKI IEFANMQQQR EEDRMAKVQE NEEKRLQLQN
   301  ALTQKLEEML RQREDLEQVR QELYQEEQAE IYKSKLKEEA EKKLRKQKEM KQDFEEQMAL
   361  KELVLQAAKE EEENFRKTML AKFAEDDRIE LMNAQKQRMK QLEHRRAVEK LIEERRQQFL
   421  ADKQRELEEW QLQQRRQGFI NAIIEEERLK LLKEHATNLL GYLPKGVFKK EDDIDLLGEE
   481  FRKVYQQRSE ICEEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MNS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • testis: 45 nTPM
  • choroid plexus: 21 nTPM
  • fallopian tube: 20 nTPM
  • kidney: 9.6 nTPM
  • cerebellum: 7.4 nTPM
  • thymus: 5.2 nTPM

Single-cell type

  • late primary spermatocytes: 964 nCPM
  • epididymal efferent duct ciliated cells: 492 nCPM
  • fallopian tube ciliated cells: 477 nCPM
  • respiratory ciliated cells: 396 nCPM
  • early spermatids: 356 nCPM
  • endometrial ciliated cells: 325 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 27 nTPM
  • cerebellum: 22 nTPM
  • medulla oblongata: 17 nTPM
  • midbrain: 15 nTPM
  • spinal cord: 14 nTPM
  • white matter: 8.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MNS1.

Disease | AllUniProt

Conditions MNS1 is implicated in, by any mechanism.

  • Heterotaxy, visceral, 9, autosomal, with male infertility (HTX9) MIM:618948

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 97 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Heterotaxy, visceral, 9, autosomal, with male infertility
  • MNS1-related disorder
  • Situs inversus

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.33
gnomAD pLI
0
gnomAD missense Z
-0.44
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MNS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MNS1 as an antibody target. Whether an autoantibody or antibody against MNS1 could matter depends on whether native MNS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MNS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MNS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MNS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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