Gasdermin, PUB domain

Definition

This entry represents the PUB domain found in Gasdermin and GSDMB [[cite:PMID:11297734], [cite:PMID:10967128]]. GSDMB (GSDM) may play a role in achieving and maintaining the final differentiation state of epithelial cells [[cite:PMID:15010812], [cite:PMID:18038310]]. A deletion/insertion mutation in GSDMB (DFNA5) is associated with an autosomal dominant non-syndromic hearing impairment form PMID:9771715. Certain gasdermins are cleaved by inflammatory and apoptotic caspases PMID:29990470. Gasmedin E is cleaved by caspase-3 and the N-terminal fragment released forms pores in the cell membrane, switching from cell death by apoptosis to pyroptosis PMID:28459430.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• GSDMA
• GSDMB
• GSDMC
• GSDMD
• GSDME