Seroatlas · Human Serome Atlas

GSDMB

Gasdermin-B

Also known as: GSDMB_HUMAN, GSDML, PRO2521

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAX9
Gene: GSDMB
Ensembl: ENSG00000073605
Chromosome: 17
Canonical length: 416 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homooligomer

OverviewNCBI Gene

This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Alternative splicing and the use of alternative promoters results in multiple transcript variants. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. [provided by RefSeq, Nov 2016]

Canonical amino-acid sequenceUniProt

416 residues, UniProt reviewed canonical sequence.

>Q8TAX9|GSDMB
     1  MFSVFEEITR IVVKEMDAGG DMIAVRSLVD ADRFRCFHLV GEKRTFFGCR HYTTGLTLMD
    61  ILDTDGDKWL DELDSGLQGQ KAEFQILDNV DSTGELIVRL PKEITISGSF QGFHHQKIKI
   121  SENRISQQYL ATLENRKLKR ELPFSFRSIN TRENLYLVTE TLETVKEETL KSDRQYKFWS
   181  QISQGHLSYK HKGQREVTIP PNRVLSYRVK QLVFPNKETM NIHFRGKTKS FPEEKDGASS
   241  CLGKSLGSED SRNMKEKLED MESVLKDLTE EKRKDVLNSL AKCLGKEDIR QDLEQRVSEV
   301  LISGELHMED PDKPLLSSLF NAAGVLVEAR AKAILDFLDA LLELSEEQQF VAEALEKGTL
   361  PLLKDQVKSV MEQNWDELAS SPPDMDYDPE ARILCALYVV VSILLELAEG PTSVSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GSDMB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 72 nTPM

Expression across tissuesHPA

Tissue

small intestine: 72 nTPM
duodenum: 63 nTPM
liver: 54 nTPM
rectum: 54 nTPM
stomach: 45 nTPM
colon: 42 nTPM

Single-cell type

enterocytes: 181 nCPM
foveolar cells: 147 nCPM
goblet cells: 82 nCPM
adipocytes: 68 nCPM
colonocytes: 62 nCPM
paneth cells: 58 nCPM

Immune cell

memory CD4 T-cell: 0.7 nTPM
naive CD4 T-cell: 0.6 nTPM
eosinophil: 0.5 nTPM
memory CD8 T-cell: 0.4 nTPM
gdT-cell: 0.3 nTPM
neutrophil: 0.3 nTPM

Brain region

cerebral cortex: 6.2 nTPM
white matter: 5.1 nTPM
cerebellum: 4.9 nTPM
basal ganglia: 4 nTPM
hippocampal formation: 3.9 nTPM
amygdala: 3.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: 0.17
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GSDMB as an antibody target. Whether an autoantibody or antibody against GSDMB could matter depends on whether native GSDMB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GSDMB is annotated at the cell surface, where native GSDMB is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GSDMB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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