Seroatlas · Human Serome Atlas

GSDMC

Gasdermin-C

Also known as: GSDMC_HUMAN, MLZE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BYG8
Gene: GSDMC
Ensembl: ENSG00000147697
Chromosome: 8
Canonical length: 508 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Vesicles
Quaternary structure: Homooligomer

OverviewNCBI Gene

Enables wide pore channel activity. Involved in pyroptotic inflammatory response. Located in cytoplasm. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

508 residues, UniProt reviewed canonical sequence.

>Q9BYG8|GSDMC
     1  MPSMLERISK NLVKEIGSKD LTPVKYLLSA TKLRQFVILR KKKDSRSSFW EQSDYVPVEF
    61  SLNDILEPSS SVLETVVTGP FHFSDIMIQK HKADMGVNVG IEVSVSGEAS VDHGCSLEFQ
   121  IVTIPSPNLE DFQKRKLLDP EPSFLKECRR RGDNLYVVTE AVELINNTVL YDSSSVNILG
   181  KIALWITYGK GQGQGESLRV KKKALTLQKG MVMAYKRKQL VIKEKAILIS DDDEQRTFQD
   241  EYEISEMVGY CAARSEGLLP SFHTISPTLF NASSNDMKLK PELFLTQQFL SGHLPKYEQV
   301  HILPVGRIEE PFWQNFKHLQ EEVFQKIKTL AQLSKDVQDV MFYSILAMLR DRGALQDLMN
   361  MLELDSSGHL DGPGGAILKK LQQDSNHAWF NPKDPILYLL EAIMVLSDFQ HDLLACSMEK
   421  RILLQQQELV RSILEPNFRY PWSIPFTLKP ELLAPLQSEG LAITYGLLEE CGLRMELDNP
   481  RSTWDVEAKM PLSALYGTLS LLQQLAEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GSDMC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

esophagus: 33 nTPM
skin: 26 nTPM
spleen: 14 nTPM
vagina: 12 nTPM
cervix: 11 nTPM
salivary gland: 5.4 nTPM

Single-cell type

suprabasal keratinocytes: 7 nCPM
papillary tip epithelial cells: 6 nCPM
esophageal apical cells: 5.3 nCPM
basal keratinocytes: 4.5 nCPM
esophageal suprabasal cells: 2.8 nCPM
epicardial cells: 2.3 nCPM

Immune cell

basophil: 0.2 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.6 nTPM
pons: 0.6 nTPM
medulla oblongata: 0.5 nTPM
white matter: 0.5 nTPM
cerebellum: 0.4 nTPM
hippocampal formation: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: -0.51
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GSDMC as an antibody target. Whether an autoantibody or antibody against GSDMC could matter depends on whether native GSDMC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GSDMC is annotated at the cell surface, where native GSDMC is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GSDMC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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