Seroatlas · Human Serome Atlas

GSDMA

Gasdermin-A

Also known as: FLJ39120, GSDM, GSDM1, GSDMA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96QA5
Gene: GSDMA
Ensembl: ENSG00000167914
Chromosome: 17
Canonical length: 445 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Nuclear bodies,Plasma membrane,Cytosol
Quaternary structure: Homooligomer

OverviewNCBI Gene

Enables wide pore channel activity. Involved in defense response to bacterium and pyroptotic inflammatory response. Located in perinuclear region of cytoplasm. Is active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

445 residues, UniProt reviewed canonical sequence.

>Q96QA5|GSDMA
     1  MTMFENVTRA LARQLNPRGD LTPLDSLIDF KRFHPFCLVL RKRKSTLFWG ARYVRTDYTL
    61  LDVLEPGSSP SDPTDTGNFG FKNMLDTRVE GDVDVPKTVK VKGTAGLSQN STLEVQTLSV
   121  APKALETVQE RKLAADHPFL KEMQDQGENL YVVMEVVETV QEVTLERAGK AEACFSLPFF
   181  APLGLQGSIN HKEAVTIPKG CVLAFRVRQL MVKGKDEWDI PHICNDNMQT FPPGEKSGEE
   241  KVILIQASDV GDVHEGFRTL KEEVQRETQQ VEKLSRVGQS SLLSSLSKLL GKKKELQDLE
   301  LALEGALDKG HEVTLEALPK DVLLSKEAVG AILYFVGALT ELSEAQQKLL VKSMEKKILP
   361  VQLKLVESTM EQNFLLDKEG VFPLQPELLS SLGDEELTLT EALVGLSGLE VQRSGPQYMW
   421  DPDTLPRLCA LYAGLSLLQQ LTKAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GSDMA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

skin: 58 nTPM
epididymis: 6.2 nTPM
breast: 3.3 nTPM
adipose tissue: 3.2 nTPM
tonsil: 3.2 nTPM
esophagus: 3 nTPM

Single-cell type

esophageal apical cells: 19 nCPM
kupffer cells: 17 nCPM
paneth cells: 12 nCPM
epididymal principal cells: 8.6 nCPM
retinal pigment epithelial cells: 8.5 nCPM
macrophages: 5 nCPM

Immune cell

MAIT T-cell: 2.6 nTPM
gdT-cell: 2.2 nTPM
memory CD4 T-cell: 1.3 nTPM
basophil: 1 nTPM
naive CD8 T-cell: 0.9 nTPM
memory CD8 T-cell: 0.8 nTPM

Brain region

medulla oblongata: 2.8 nTPM
thalamus: 2.8 nTPM
cerebral cortex: 2.7 nTPM
pons: 2.7 nTPM
white matter: 2.7 nTPM
cerebellum: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: 0.28
DepMap mean gene effect: -0.31
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GSDMA as an antibody target. Whether an autoantibody or antibody against GSDMA could matter depends on whether native GSDMA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GSDMA is annotated at the cell surface, where native GSDMA is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GSDMA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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