DNA mismatch repair protein MutL/Mlh/Pms-like

Definition

Mismatch repair contributes to the overall fidelity of DNA replication by targeting mispaired bases that arise through replication errors during homologous recombination and as a result of DNA damage. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex PMID:14527292. This entry represents a family of evolutionarily related DNA mismatch repair proteins, including MutL, Mlh1, Mlh2 and Mlh3, and Pms 1 and 2. Bacterial MutL proteins are homodimers, while their eukaryotic homologues form heterodimers consisting of the MutL homologue Mlh1 and either Pms1, Pms2 or Mlh3 [[cite:PMID:26436461], [cite:PMID:10570173], [cite:PMID:35189042]]. MutL homologues share a conserved ATP binding site PMID:11717305.

8 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (8 proteins: gene, accession, name)

• MLH1
• MLH3
• PMS1
• PMS2
• PMS2P1
• PMS2P2
• PMS2P3
• PMS2P5