Seroatlas · Human Serome Atlas

PMS2P2

Putative postmeiotic segregation increased 2-like protein 2

Also known as: PM2P2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95744
Gene: PMS2P2
Canonical length: 297 aa

OverviewNCBI Gene

No narrative summary is available for PMS2P2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

297 residues, UniProt reviewed canonical sequence.

>O95744|PMS2P2
     1  MGESSRKPPT PTPEGPTVSV KQLFSTLPVR HKEFQRNIKK KRACFPFAFC RDCQFLEGSP
    61  AMLPVQPAKL TEPAKAIKPI DRKSVHQICS GPVVLSLSTA VKKIVGNSLD AGATNIDLKL
   121  KDYGMDLIEV SGNGCGVEEE NFEGLSLSAL KHHTSKIREF ADLTRVETFG FQGKALSSLC
   181  ALSDVTISTC HVSAKVGTRL VFDHDGKIIK KTPYPHPRGT TVSVKQLFST LPVRHKEFQR
   241  NIKKKRACFP FAFCRDCQFL EGSPAMLPVQ PAKLTVTGEL RACRSWKTRE GITEAVG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PMS2P2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4

OntologyGO

Biological processes

mismatch repair

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PMS2P2 as an antibody target. Whether an autoantibody or antibody against PMS2P2 could matter depends on whether native PMS2P2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PMS2P2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PMS2P2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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