Seroatlas · Human Serome Atlas

PMS2P1

Putative postmeiotic segregation increased 2-like protein 1

Also known as: PM2P1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A4D2B8
Gene: PMS2P1
Canonical length: 440 aa

OverviewNCBI Gene

No narrative summary is available for PMS2P1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

440 residues, UniProt reviewed canonical sequence.

>A4D2B8|PMS2P1
     1  MVTMCGGHRP ENFLHQVLTE FGEELAGEGK SEVGGGAPRS YLQVASAECW AAAPAVHVGE
    61  PVHAGGLHTE RGADPVIGLY LVHRGGACQT PTVGNRQTPT LGIHARPRRR ATTSLLTLLL
   121  AFGKNAVRCA LIGPGSLTSR TRPLTEPLGE KERREVFFPP RPERVEHNVE SSRWEPRRRG
   181  ACGSRGGNFP SPRGGSGVAS LERAESSSTE PAKAIKPIDR KSVHQICSGP VVPSLSTAVK
   241  ELVENSLDAG ATNIDLKLKD YGVDLIEVSG NGCGVEEENF EGLTLKHHTS KIQEFADLPQ
   301  VETFGFRGEA LSSLCALSDV TISTCHVSAK VGTRLVFDHY GKIIQKTPYP HPRGMTVSVK
   361  QLFSTLPVHH KEFQRNIKKK RACFPFAFCR DCQFPEASPA MLPVQPAELT PRSTPPHPCS
   421  LEDNVITVFS SVKNGPGSSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PMS2P1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51

OntologyGO

Biological processes

mismatch repair

Molecular functions

Cellular components

mismatch repair complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PMS2P1 as an antibody target. Whether an autoantibody or antibody against PMS2P1 could matter depends on whether native PMS2P1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PMS2P1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PMS2P1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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