Seroatlas · Human Serome Atlas

PMS2P3

Putative postmeiotic segregation increased 2-like protein 3

Also known as: PM2P3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13401
Gene: PMS2P3
Canonical length: 168 aa

OverviewNCBI Gene

No narrative summary is available for PMS2P3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

168 residues, UniProt reviewed canonical sequence.

>Q13401|PMS2P3
     1  MNTLQGPVSF KDVAVDFTQE EWRQLDPDEK IAYGDVMLEN YSHLVSVGYD YHQAKHHHGV
    61  EVKEVEQGEE PWIMEGEFPC QHSPEPAKAI KPIDRKSVHQ ICSGPVVLSL STAVKELVEN
   121  SLDAGATNID LKLKDYGVDL IEVSDNGCGV EEENFEGLIS FSSETSHM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PMS2P3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

mismatch repair complex

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PMS2P3 as an antibody target. Whether an autoantibody or antibody against PMS2P3 could matter depends on whether native PMS2P3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PMS2P3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PMS2P3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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