Seroatlas · Human Serome Atlas

PMS2P5

Postmeiotic segregation increased 2-like protein 5

Also known as: PM2P5_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MQ11
Gene: PMS2P5
Canonical length: 134 aa

OverviewNCBI Gene

No narrative summary is available for PMS2P5 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

134 residues, UniProt reviewed canonical sequence.

>A8MQ11|PMS2P5
     1  MWGRRRKLRR LNDVTISTCH VSAKVGTRLV FDHDGKIIQK TPYPHPRGTT VSVKQLFSTL
    61  PVRHKEFQRN IKKKRACFPF AFCRDCQFLE GSPAMLPVQP AKLTPRSTPP HPCSLEDNVI
   121  TVFSSVKNGP GSSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PMS2P5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47

OntologyGO

Biological processes

mismatch repair

Molecular functions

Cellular components

mismatch repair complex

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PMS2P5 as an antibody target. Whether an autoantibody or antibody against PMS2P5 could matter depends on whether native PMS2P5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PMS2P5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PMS2P5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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