Seroatlas · Human Serome Atlas

UNC5D

Netrin receptor UNC5D

Also known as: KIAA1777, UNC5D_HUMAN, Unc5h4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UXZ4
Gene
UNC5D
Ensembl
ENSG00000156687
Chromosome
8
Canonical length
953 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable netrin receptor activity. Involved in cell-cell adhesion via plasma-membrane adhesion molecules. Predicted to be located in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

953 residues, UniProt reviewed canonical sequence.

>Q6UXZ4|UNC5D
     1  MGRAAATAGG GGGARRWLPW LGLCFWAAGT AAARGTDNGE ALPESIPSAP GTLPHFIEEP
    61  DDAYIIKSNP IALRCKARPA MQIFFKCNGE WVHQNEHVSE ETLDESSGLK VREVFINVTR
   121  QQVEDFHGPE DYWCQCVAWS HLGTSKSRKA SVRIAYLRKN FEQDPQGREV PIEGMIVLHC
   181  RPPEGVPAAE VEWLKNEEPI DSEQDENIDT RADHNLIIRQ ARLSDSGNYT CMAANIVAKR
   241  RSLSATVVVY VNGGWSSWTE WSACNVRCGR GWQKRSRTCT NPAPLNGGAF CEGMSVQKIT
   301  CTSLCPVDGS WEVWSEWSVC SPECEHLRIR ECTAPPPRNG GKFCEGLSQE SENCTDGLCI
   361  LDKKPLHEIK PQSIENASDI ALYSGLGAAV VAVAVLVIGV TLYRRSQSDY GVDVIDSSAL
   421  TGGFQTFNFK TVRQGNSLLL NSAMQPDLTV SRTYSGPICL QDPLDKELMT ESSLFNPLSD
   481  IKVKVQSSFM VSLGVSERAE YHGKNHSRTF PHGNNHSFST MHPRNKMPYI QNLSSLPTRT
   541  ELRTTGVFGH LGGRLVMPNT GVSLLIPHGA IPEENSWEIY MSINQGEPSL QSDGSEVLLS
   601  PEVTCGPPDM IVTTPFALTI PHCADVSSEH WNIHLKKRTQ QGKWEEVMSV EDESTSCYCL
   661  LDPFACHVLL DSFGTYALTG EPITDCAVKQ LKVAVFGCMS CNSLDYNLRV YCVDNTPCAF
   721  QEVVSDERHQ GGQLLEEPKL LHFKGNTFSL QISVLDIPPF LWRIKPFTAC QEVPFSRVWC
   781  SNRQPLHCAF SLERYTPTTT QLSCKICIRQ LKGHEQILQV QTSILESERE TITFFAQEDS
   841  TFPAQTGPKA FKIPYSIRQR ICATFDTPNA KGKDWQMLAQ KNSINRNLSY FATQSSPSAV
   901  ILNLWEARHQ HDGDLDSLAC ALEEIGRTHT KLSNISESQL DEADFNYSRQ NGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UNC5D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
5.6 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 5.6 nTPM
  • cerebral cortex: 4.8 nTPM
  • prostate: 4.5 nTPM
  • retina: 4.5 nTPM
  • hypothalamus: 4 nTPM
  • pituitary gland: 3 nTPM

Single-cell type

  • pituicytes/fscs: 1,683 nCPM
  • brain inhibitory neurons: 1,092 nCPM
  • other brain neurons: 1000 nCPM
  • lactotrophs: 891 nCPM
  • retinal bipolar cells: 792 nCPM
  • retinal horizontal cells: 759 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 61 nTPM
  • cerebral cortex: 23 nTPM
  • basal ganglia: 22 nTPM
  • midbrain: 18 nTPM
  • amygdala: 17 nTPM
  • white matter: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.33
gnomAD pLI
0.93
gnomAD missense Z
2.25
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UNC5D as an antibody target. Whether an autoantibody or antibody against UNC5D could matter depends on whether native UNC5D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UNC5D is annotated at the cell surface, where native UNC5D is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label UNC5D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UNC5D. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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