EXPERA domain

Definition

The EXPERA (EXPanded EBP superfamilly) domain is conserved among the following protein families: Vertebrate TM6SF1 (Transmembrane 6 Superfamily Member 1). Vertebrate TM6SF2 (Transmembrane 6 Superfamily Member 2). Eukaryotic MAC30 (Meningioma-associated protein 30) also known as TMEM97 (Transmembrane protein 97), mainly localized in the endoplasmic reticulum (ER). Eukaryotic EBP (Emopamil binding protein), an enzyme with a D8, D7 sterol isomerase activity that catalyzes the transposition of a double bond from C8=C9 to C7=C8 in the sterol B-ring. The EXPERA domain contains four transmembrane regions and is likely to possess a sterol isomerase catalytic activity PMID:25566323.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• EBP
• EBPL
• TM6SF1
• TM6SF2
• TMEM97