Seroatlas · Human Serome Atlas

TM6SF1

Transmembrane 6 superfamily member 1

Also known as: TM6S1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZW5
Gene: TM6SF1
Ensembl: ENSG00000136404
Chromosome: 15
Canonical length: 370 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to be located in lysosome and membrane. Predicted to be active in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

370 residues, UniProt reviewed canonical sequence.

>Q9BZW5|TM6SF1
     1  MSASAATGVF VLSLSAIPVT YVFNHLAAQH DSWTIVGVAA LILFLVALLA RVLVKRKPPR
    61  DPLFYVYAVF GFTSVVNLII GLEQDGIIDG FMTHYLREGE PYLNTAYGHM ICYWDGSAHY
   121  LMYLVMVAAI AWEETYRTIG LYWVGSIIMS VVVFVPGNIV GKYGTRICPA FFLSIPYTCL
   181  PVWAGFRIYN QPSENYNYPS KVIQEAQAKD LLRRPFDLML VVCLLLATGF CLFRGLIALD
   241  CPSELCRLYT QFQEPYLKDP AAYPKIQMLA YMFYSVPYFV TALYGLVVPG CSWMPDITLI
   301  HAGGLAQAQF SHIGASLHAR TAYVYRVPEE AKILFLALNI AYGVLPQLLA YRCIYKPEFF
   361  IKTKAEEKVE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TM6SF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 44 nTPM
tongue: 20 nTPM
lung: 10 nTPM
cerebral cortex: 9.9 nTPM
thyroid gland: 9.7 nTPM
heart muscle: 8.9 nTPM

Single-cell type

microglia: 216 nCPM
neutrophils: 115 nCPM
megakaryocytes: 105 nCPM
macrophages: 90 nCPM
myonuclei: 89 nCPM
neutrophil progenitors: 85 nCPM

Immune cell

eosinophil: 196 nTPM
neutrophil: 119 nTPM
basophil: 77 nTPM
classical monocyte: 32 nTPM
myeloid DC: 19 nTPM
intermediate monocyte: 14 nTPM

Brain region

cerebellum: 16 nTPM
white matter: 16 nTPM
spinal cord: 15 nTPM
medulla oblongata: 14 nTPM
pons: 14 nTPM
choroid plexus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: 1
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

lysosomal membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TM6SF1 as an antibody target. Whether an autoantibody or antibody against TM6SF1 could matter depends on whether native TM6SF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TM6SF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TM6SF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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