EBPL
Emopamil-binding protein-like
Also known as: EBPL_HUMAN, EBRP
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BY08
- Gene
- EBPL
- Ensembl
- ENSG00000123179
- Chromosome
- 13
- Canonical length
- 206 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Endoplasmic reticulum
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Predicted to enable cholestenol delta-isomerase activity. Predicted to be involved in sterol metabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
206 residues, UniProt reviewed canonical sequence.
>Q9BY08|EBPL
1 MGAEWELGAE AGGSLLLCAA LLAAGCALGL RLGRGQGAAD RGALIWLCYD ALVHFALEGP
61 FVYLSLVGNV ANSDGLIASL WKEYGKADAR WVYFDPTIVS VEILTVALDG SLALFLIYAI
121 VKEKYYRHFL QITLCVCELY GCWMTFLPEW LTRSPNLNTS NWLYCWLYLF FFNGVWVLIP
181 GLLLWQSWLE LKKMHQKETS SVKKFQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against EBPL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 93 nTPM
Expression across tissuesHPA
Tissue
- liver: 93 nTPM
- esophagus: 48 nTPM
- adrenal gland: 46 nTPM
- pancreas: 39 nTPM
- vagina: 38 nTPM
- cervix: 33 nTPM
Single-cell type
- esophageal suprabasal cells: 510 nCPM
- esophageal basal cells: 384 nCPM
- hepatocytes: 350 nCPM
- suprabasal keratinocytes: 239 nCPM
- oocytes: 235 nCPM
- gastric progenitor cells: 231 nCPM
Immune cell
- naive CD4 T-cell: 6.9 nTPM
- MAIT T-cell: 6.7 nTPM
- neutrophil: 5.5 nTPM
- naive B-cell: 5.1 nTPM
- memory CD8 T-cell: 4.9 nTPM
- myeloid DC: 4.9 nTPM
Brain region
- white matter: 15 nTPM
- spinal cord: 14 nTPM
- hypothalamus: 13 nTPM
- choroid plexus: 13 nTPM
- thalamus: 12 nTPM
- pons: 12 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.48
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.02
- DepMap mean gene effect
- -0.1
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads EBPL as an antibody target. Whether an autoantibody or antibody against EBPL could matter depends on whether native EBPL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
EBPL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label EBPL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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