Lipid binding protein BPI/LBP

Definition

This entry represents the bactericidal permeability-increasing protein (BPI) and the lipopolysaccharide-binding protein (LBP). The crystal structures of BPI and LBP are similar PMID:9188532, and they may represent a common gene family of lipid-binding proteins PMID:9441745. In mammals, LBP and BPI mediate the biological effects of LPS (lipopolysaccharide), a glycolipid present in the outer membrane of Gram-negative bacteria. LBP is a plasma protein that enhances the inflammatory response to LPS, whereas BPI is found in lysosomal granules of polymorphonuclear neutrophils, is bactericidal, and neutralises the toxic effects of LPS [[cite:PMID:7613727], [cite:PMID:7517398]].

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• BPI
• BPIFB2
• BPIFC
• LBP
• PLTP