BPI

Protein identityUniProt · HPA

UniProt accession

P17213

Gene

BPI

Ensembl

ENSG00000101425

Chromosome

20

Canonical length

487 aa

Protein class

Predicted intracellular proteins, Predicted secreted proteins, Transporters

Secretome location

Secreted to blood

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014]

Canonical amino-acid sequenceUniProt

487 residues, UniProt reviewed canonical sequence.

>P17213|BPI
     1  MRENMARGPC NAPRWASLMV LVAIGTAVTA AVNPGVVVRI SQKGLDYASQ QGTAALQKEL
    61  KRIKIPDYSD SFKIKHLGKG HYSFYSMDIR EFQLPSSQIS MVPNVGLKFS ISNANIKISG
   121  KWKAQKRFLK MSGNFDLSIE GMSISADLKL GSNPTSGKPT ITCSSCSSHI NSVHVHISKS
   181  KVGWLIQLFH KKIESALRNK MNSQVCEKVT NSVSSELQPY FQTLPVMTKI DSVAGINYGL
   241  VAPPATTAET LDVQMKGEFY SENHHNPPPF APPVMEFPAA HDRMVYLGLS DYFFNTAGLV
   301  YQEAGVLKMT LRDDMIPKES KFRLTTKFFG TFLPEVAKKF PNMKIQIHVS ASTPPHLSVQ
   361  PTGLTFYPAV DVQAFAVLPN SSLASLFLIG MHTTGSMEVS AESNRLVGEL KLDRLLLELK
   421  HSNIGPFPVE LLQDIMNYIV PILVLPRVNE KLQKGFPLPT PARVQLYNVV LQPHQNFLLF
   481  GADVVYK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BPI can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

1,420 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BPI.

Disease | AutoantibodyPubMed

Conditions in which antibodies against BPI are reported. Each links to that disease's full target list.

• Vasculitis 7
• Colitis, Ulcerative 5
• Arthritis, Rheumatoid 4
• Crohn Disease 3

Showing 4 of 7 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for BPI from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.25

gnomAD pLI

0

gnomAD missense Z

-0.78

DepMap mean gene effect

0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• defense response to Gram-negative bacterium
• innate immune response
• lipopolysaccharide-mediated signaling pathway
• negative regulation of interleukin-6 production
• negative regulation of interleukin-8 production
• negative regulation of macrophage activation
• negative regulation of tumor necrosis factor production

Molecular functions

• lipopolysaccharide binding

Cellular components

• azurophil granule lumen
• extracellular exosome
• extracellular region
• extracellular space
• specific granule lumen

Protein domainsUniProt · Pfam · InterPro

• Lipid-binding serum glycoprotein, C-terminal
• Lipid-binding serum glycoprotein, N-terminal
• Bactericidal permeability-increasing protein, alpha/beta domain superfamily
• Lipid-binding serum glycoprotein, conserved site
• Lipid binding protein BPI/LBP
• BPI/LBP/Plunc family
• LBP / BPI / CETP family, N-terminal domain
• LBP / BPI / CETP family, C-terminal domain

KeywordsUniProt

• Antibiotic
• Antimicrobial
• Disulfide bond
• Glycoprotein
• Immunity
• Innate immunity
• Membrane
• Secreted
• Signal