Seroatlas · Human Serome Atlas

PLTP

Phospholipid transfer protein

Also known as: BPIFE, PLTP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P55058
Gene
PLTP
Ensembl
ENSG00000100979
Chromosome
20
Canonical length
493 aa
Protein class
Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, Transporters
Secretome location
Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

493 residues, UniProt reviewed canonical sequence.

>P55058|PLTP
     1  MALFGALFLA LLAGAHAEFP GCKIRVTSKA LELVKQEGLR FLEQELETIT IPDLRGKEGH
    61  FYYNISEVKV TELQLTSSEL DFQPQQELML QITNASLGLR FRRQLLYWFF YDGGYINASA
   121  EGVSIRTGLE LSRDPAGRMK VSNVSCQASV SRMHAAFGGT FKKVYDFLST FITSGMRFLL
   181  NQQICPVLYH AGTVLLNSLL DTVPVRSSVD ELVGIDYSLM KDPVASTSNL DMDFRGAFFP
   241  LTERNWSLPN RAVEPQLQEE ERMVYVAFSE FFFDSAMESY FRAGALQLLL VGDKVPHDLD
   301  MLLRATYFGS IVLLSPAVID SPLKLELRVL APPRCTIKPS GTTISVTASV TIALVPPDQP
   361  EVQLSSMTMD ARLSAKMALR GKALRTQLDL RRFRIYSNHS ALESLALIPL QAPLKTMLQI
   421  GVMPMLNERT WRGVQIPLPE GINFVHEVVT NHAGFLTIGA DLHFAKGLRE VIEKNRPADV
   481  RASTAPTPST AAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLTP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
409 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 409 nTPM
  • placenta: 403 nTPM
  • choroid plexus: 403 nTPM
  • urinary bladder: 316 nTPM
  • pancreas: 280 nTPM
  • thymus: 214 nTPM

Single-cell type

  • hofbauer cells: 3,539 nCPM
  • kupffer cells: 702 nCPM
  • macrophages: 380 nCPM
  • epididymal efferent duct ciliated cells: 321 nCPM
  • leydig cells: 308 nCPM
  • decidual stromal cells: 253 nCPM

Immune cell

  • basophil: 33 nTPM
  • eosinophil: 30 nTPM
  • plasmacytoid DC: 18 nTPM
  • non-classical monocyte: 13 nTPM
  • memory B-cell: 8.7 nTPM
  • intermediate monocyte: 7.1 nTPM

Brain region

  • choroid plexus: 300 nTPM
  • midbrain: 206 nTPM
  • pons: 151 nTPM
  • spinal cord: 148 nTPM
  • medulla oblongata: 140 nTPM
  • hypothalamus: 136 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.04
gnomAD pLI
0
gnomAD missense Z
-0.02
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLTP as an antibody target. Whether an autoantibody or antibody against PLTP could matter depends on whether native PLTP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLTP is annotated as secreted, so native PLTP circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PLTP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLTP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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