Seroatlas · Human Serome Atlas

BPIFB2

BPI fold-containing family B member 2

Also known as: BPIB2_HUMAN, BPIL1, C20orf184, dJ726C3.2, LPLUNC2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N4F0
Gene: BPIFB2
Ensembl: ENSG00000078898
Chromosome: 20
Canonical length: 458 aa
Protein class: Plasma proteins, Predicted secreted proteins, Transporters
Subcellular location: Vesicles
Secretome location: Secreted in other tissues

OverviewNCBI Gene

This gene encodes a member of the lipid transfer/lipopolysaccharide binding protein (LT/LBP) gene family. It is highly expressed in hypertrophic tonsils. This gene and three other members of the LT/LBP gene family form a cluster on the long arm of chromosome 20. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

458 residues, UniProt reviewed canonical sequence.

>Q8N4F0|BPIFB2
     1  MAWASRLGLL LALLLPVVGA STPGTVVRLN KAALSYVSEI GKAPLQRALQ VTVPHFLDWS
    61  GEALQPTRIR ILNVHVPRLH LKFIAGFGVR LLAAANFTFK VFRAPEPLEL TLPVELLADT
   121  RVTQSSIRTP VVSISACSLF SGHANEFDGS NSTSHALLVL VQKHIKAVLS NKLCLSISNL
   181  VQGVNVHLGT LIGLNPVGPE SQIRYSMVSV PTVTSDYISL EVNAVLFLLG KPIILPTDAT
   241  PFVLPRHVGT EGSMATVGLS QQLFDSALLL LQKAGALNLD ITGQLRSDDN LLNTSALGRL
   301  IPEVARQFPE PMPVVLKVRL GATPVAMLHT NNATLRLQPF VEVLATASNS AFQSLFSLDV
   361  VVNLRLQLSV SKVKLQGTTS VLGDVQLTVA SSNVGFIDTD QVRTLMGTVF EKPLLDHLNA
   421  LLAMGIALPG VVNLHYVAPE IFVYEGYVVI SSGLFYQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BPIFB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 2,419 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 2,419 nTPM
esophagus: 94 nTPM
cervix: 2.5 nTPM
prostate: 1.7 nTPM
tonsil: 1.7 nTPM
lung: 0.9 nTPM

Single-cell type

submucosal glandular cells: 686 nCPM
salivary acinar cells: 89 nCPM
breast hormone-responsive cells: 18 nCPM
late spermatids: 18 nCPM
respiratory secretory cells: 8.2 nCPM
prostatic glandular cells: 6.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 0.1 nTPM
midbrain: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
gnomAD missense Z: 0.32
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

lipid binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BPIFB2 as an antibody target. Whether an autoantibody or antibody against BPIFB2 could matter depends on whether native BPIFB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BPIFB2 is annotated as secreted, so native BPIFB2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label BPIFB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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