Seroatlas · Human Serome Atlas

BPIFC

BPI fold-containing family C protein

Also known as: BPIFC_HUMAN, BPIL2, dJ149A16.7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NFQ6
Gene: BPIFC
Ensembl: ENSG00000184459
Chromosome: 22
Canonical length: 507 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Predicted to enable lipopolysaccharide binding activity and phospholipid binding activity. Predicted to be involved in defense response to Gram-negative bacterium and innate immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

507 residues, UniProt reviewed canonical sequence.

>Q8NFQ6|BPIFC
     1  MCTKTIPVLW GCFLLWNLYV SSSQTIYPGI KARITQRALD YGVQAGMKMI EQMLKEKKLP
    61  DLSGSESLEF LKVDYVNYNF SNIKISAFSF PNTSLAFVPG VGIKALTNHG TANISTDWGF
   121  ESPLFQDTGG ADLFLSGVYF TGIIILTRND FGHPTLKLQD CYAQLSHAHV SFSGELSVLY
   181  NSFAEPMEKP ILKNLNEMLC PIIASEVKAL NANLSTLEVL TKIDNYTLLD YSLISSPEIT
   241  ENYLDLNLKG VFYPLENLTD PPFSPVPFVL PERSNSMLYI GIAEYFFKSA SFAHFTAGVF
   301  NVTLSTEEIS NHFVQNSQGL GNVLSRIAEI YILSQPFMVR IMATEPPIIN LQPGNFTLDI
   361  PASIMMLTQP KNSTVETIVS MDFVASTSVG LVILGQRLVC SLSLNRFRLA LPESNRSNIE
   421  VLRFENILSS ILHFGVLPLA NAKLQQGFPL SNPHKFLFVN SDIEVLEGFL LISTDLKYET
   481  SSKQQPSFHV WEGLNLISRQ WRGKSAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BPIFC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

skin: 43 nTPM
breast: 2.2 nTPM
testis: 1.5 nTPM
cervix: 0.8 nTPM
tonsil: 0.6 nTPM
vagina: 0.4 nTPM

Single-cell type

early spermatids: 24 nCPM
late primary spermatocytes: 18 nCPM
late spermatids: 13 nCPM
suprabasal keratinocytes: 10 nCPM
retinal horizontal cells: 4 nCPM
retinal ganglion cells: 3.9 nCPM

Immune cell

basophil: 1.5 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.5 nTPM
hypothalamus: 0.4 nTPM
amygdala: 0.3 nTPM
basal ganglia: 0.1 nTPM
hippocampal formation: 0.1 nTPM
medulla oblongata: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0
gnomAD missense Z: 0.52
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

innate immune response

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BPIFC as an antibody target. Whether an autoantibody or antibody against BPIFC could matter depends on whether native BPIFC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BPIFC is annotated as secreted, so native BPIFC circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label BPIFC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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