DMRT family
IPR026607
Definition
The DMRT family contains putative transcription factors related to the sexual regulators doublesex (Drosophila melanogaster) and mab-3 (Caenorhabditis elegans). Its members are involved in sex determination/differentiation PMID:15008421. Mab-3 promotes male-specific development of two tissues. In the peripheral nervous system, it directs differentiation of sensory ray neuroblasts into peripheral sense organs. In the intestine, It causes repression of vitellogenin gene transcription. It binds the DNA motif 5'-[CGA][TCA][TA]ACAATGT[AT][TGA]C-3', probably as a monomer PMID:9490411.
8 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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