Seroatlas · Human Serome Atlas

DMRTC2

Doublesex- and mab-3-related transcription factor C2

Also known as: DMRTD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IXT2
Gene: DMRTC2
Ensembl: ENSG00000142025
Chromosome: 19
Canonical length: 367 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in cell differentiation; regulation of transcription by RNA polymerase II; and sex differentiation. Predicted to act upstream of or within heterochromatin organization; male meiosis I; and spermatid nucleus elongation. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

367 residues, UniProt reviewed canonical sequence.

>Q8IXT2|DMRTC2
     1  MEPSDMPAGY HCPLDSAPWD ETRDPQSTEL IPRRAISRSP TCARCRNHGV TAHLKGHKRL
    61  CLFQACECHK CVLILERRRV MAAQVALRRQ QEAQLKKHLM RRGEASPKAP NHFRKGTTQP
   121  QVPSGKENIA PQPQTPHGAV LLAPTPPGKN SCGPLLLSHP PEASPLSWTP VPPGPWVPGH
   181  WLPPGFSMPP PVVCRLLYQE PAVSLPPFPG FDPGTSLQLP THGPFTTCPG SHPVLTAPLS
   241  GEPQGPPSQP RTHSTLILQP CGTPDPLQLQ PQASGASCLA RTSGPSEWQL QQEAAEALVG
   301  LKDSSQAPRV TPSVPPNPAW ISLLHPCGPP APAGGRGFQP VGPCLRPSPA PSVALHIGRL
   361  GSISLLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DMRTC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

testis: 39 nTPM
bone marrow: 0.3 nTPM
retina: 0.3 nTPM
lymph node: 0.2 nTPM
appendix: 0.1 nTPM
breast: 0.1 nTPM

Single-cell type

early primary spermatocytes: 347 nCPM
differentiating spermatogonia: 41 nCPM
late primary spermatocytes: 29 nCPM
undifferentiated spermatogonia: 28 nCPM
late spermatids: 3.2 nCPM
neutrophils: 2.9 nCPM

Immune cell

basophil: 0.1 nTPM
neutrophil: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

medulla oblongata: 0.9 nTPM
cerebellum: 0.8 nTPM
cerebral cortex: 0.8 nTPM
amygdala: 0.7 nTPM
choroid plexus: 0.7 nTPM
hypothalamus: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0.73
gnomAD missense Z: 0.91
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DMRTC2 as an antibody target. Whether an autoantibody or antibody against DMRTC2 could matter depends on whether native DMRTC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DMRTC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DMRTC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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