Seroatlas · Human Serome Atlas

DMRTC1

Doublesex- and mab-3-related transcription factor C1

Also known as: DMRTC_HUMAN, DMRTC1B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5HYR2
Gene: DMRTC1
Ensembl: ENSG00000269502
Chromosome: X
Canonical length: 192 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Intermediate filaments

OverviewNCBI Gene

Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

192 residues, UniProt reviewed canonical sequence.

>Q5HYR2|DMRTC1
     1  MAAPPKAPIR VRNLTIRAGA LTGKENNMLQ PETHIFTAPE EGSSQGALLL GQAPEPLSLP
    61  CTPVTLEQQL VSPSGDPHRA PALPSICSTL ILQPCATLDP LLLQPQVPKV SDQALVSAHS
   121  EWQRKLEAAE ALLTLRNSAQ APPDSISLHQ PCNPPAPAGD KGFQPPSPSL RPRPASSISL
   181  PIGHLGCISL LS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DMRTC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 20 nTPM
basal ganglia: 20 nTPM
cerebral cortex: 17 nTPM
pituitary gland: 16 nTPM
amygdala: 16 nTPM
hippocampal formation: 14 nTPM

Single-cell type

adrenal medulla cells: 11 nCPM
gonadotrophs: 4.3 nCPM
lactotrophs: 4.2 nCPM
somatotrophs: 3.7 nCPM
thyrotrophs: 3.4 nCPM
brain inhibitory neurons: 2.5 nCPM

Immune cell

naive CD8 T-cell: 0.5 nTPM
naive B-cell: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM
memory B-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM

Brain region

hypothalamus: 33 nTPM
amygdala: 33 nTPM
cerebral cortex: 32 nTPM
basal ganglia: 32 nTPM
hippocampal formation: 29 nTPM
midbrain: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0.02
gnomAD missense Z: 0.86

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DMRTC1 as an antibody target. Whether an autoantibody or antibody against DMRTC1 could matter depends on whether native DMRTC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DMRTC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DMRTC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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