Seroatlas · Human Serome Atlas

DMRTA1

Doublesex- and mab-3-related transcription factor A1

Also known as: DMRTA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VZB9
Gene: DMRTA1
Ensembl: ENSG00000176399
Chromosome: 9
Canonical length: 504 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Vesicles

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II and sex differentiation. Predicted to act upstream of or within male mating behavior and ovarian follicle development. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

504 residues, UniProt reviewed canonical sequence.

>Q5VZB9|DMRTA1
     1  MERSQCGSRD RGVSGRPHLA PGLVVAAPPP PSPALPVPSG MQVPPAFLRP PSLFLRAAAA
    61  AAAAAAATSG SGGCPPAPGL ESGVGAVGCG YPRTPKCARC RNHGVVSALK GHKRFCRWRD
   121  CACAKCTLIA ERQRVMAAQV ALRRQQAQEE SEARGLQRLL CSGLSWPPGG RASGGGGRAE
   181  NPQSTGGPAA GAALGLGALR QASGSATPAF EVFQQDYPEE KQEQKESKCE SCQNGQEELI
   241  SKSHQLYLGS SSRSNGVIGK QSIGSSISEY SNKPDSILSP HPGEQSGGEE SPRSLSSSDL
   301  ESGNESEWVK DLTATKASLP TVSSRPRDPL DILTKIFPNY RRSRLEGILR FCKGDVVQAI
   361  EQVLNGKEHK PDNRNLANSE ELENTAFQRA SSFSLAGIGF GTLGNKSAFS PLQTTSASYG
   421  GDSSLYGVNP RVGISPLRLA YSSAGRGLSG FMSPYLTPGL VPTLPFRPAL DYAFSGMIRD
   481  SSYLSSKDSI TCGRLYFRPN QDNP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DMRTA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 7.8 nTPM

Expression across tissuesHPA

Tissue

liver: 7.8 nTPM
salivary gland: 3.3 nTPM
kidney: 3.2 nTPM
parathyroid gland: 2.1 nTPM
stomach: 1.9 nTPM
adipose tissue: 1.7 nTPM

Single-cell type

retinal pigment epithelial cells: 43 nCPM
hepatocytes: 36 nCPM
esophageal suprabasal cells: 28 nCPM
esophageal apical cells: 23 nCPM
salivary acinar cells: 18 nCPM
endometrial luminal cells: 17 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 4.9 nTPM
midbrain: 3.1 nTPM
thalamus: 1.3 nTPM
hippocampal formation: 1.1 nTPM
amygdala: 0.7 nTPM
basal ganglia: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: -1.18
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DMRTA1 as an antibody target. Whether an autoantibody or antibody against DMRTA1 could matter depends on whether native DMRTA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DMRTA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DMRTA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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