Seroatlas · Human Serome Atlas

DMRT3

Doublesex- and mab-3-related transcription factor 3

Also known as: DMRT3_HUMAN, DMRTA3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NQL9
Gene: DMRT3
Ensembl: ENSG00000064218
Chromosome: 9
Canonical length: 472 aa
Protein class: Predicted intracellular proteins, Transcription factors
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in male sex differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including adult walking behavior; regulation of odontogenesis of dentin-containing tooth; and ventral spinal cord interneuron specification. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

472 residues, UniProt reviewed canonical sequence.

>Q9NQL9|DMRT3
     1  MNGYGSPYLY MGGPVSQPPR APLQRTPKCA RCRNHGVLSW LKGHKRYCRF KDCTCEKCIL
    61  IIERQRVMAA QVALRRQQAN ESLESLIPDS LRALPGPPPP GDAVAAPQPP PASQPSQPQP
   121  PRPAAELAAA AALRWTAEPQ PGALQAQLAK PDLTEERLGD GKSADNTEVF SDKDTDQRSS
   181  PDVAKSKGCF TPESPEIVSV EEGGYAVQKN GGNPESRPDS PKCHAEQNHL LIEGPSGTVS
   241  LPFSLKANRP PLEVLKKIFP NQKPTVLELI LKGCGGDLVS AVEVLLSSRS SVTGAERTSA
   301  EPESLALPSN GHIFEHTLSS YPISSSKWSV GSAFRVPDTL RFSADSSNVV PSPLAGPLQP
   361  PFPQPPRYPL MLRNTLARSQ SSPFLPNDVT LWNTMTLQQQ YQLRSQYVSP FPSNSTSVFR
   421  SSPVLPARAT EDPRISIPDD GCPFVSKQSI YTEDDYDERS DSSDSRTLNT SS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DMRT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 25 nTPM
choroid plexus: 9.3 nTPM
testis: 9.1 nTPM
thyroid gland: 5 nTPM
adipose tissue: 2.9 nTPM
lymph node: 1.8 nTPM

Single-cell type

early primary spermatocytes: 31 nCPM
choroid plexus epithelial cells: 20 nCPM
respiratory secretory cells: 14 nCPM
respiratory basal cells: 12 nCPM
respiratory deuterosomal cells: 10 nCPM
ependymal cells: 9.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 22 nTPM
hippocampal formation: 2.9 nTPM
white matter: 2.9 nTPM
cerebral cortex: 2.2 nTPM
amygdala: 1.5 nTPM
medulla oblongata: 0.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DMRT3.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 126 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Premature ovarian failure

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: -1.69
DepMap mean gene effect: 0.19
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DMRT3 as an antibody target. Whether an autoantibody or antibody against DMRT3 could matter depends on whether native DMRT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DMRT3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DMRT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...