Seroatlas · Human Serome Atlas

SUN3

SUN domain-containing protein 3

Also known as: MGC33329, SUN3_HUMAN, SUNC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAQ9
Gene: SUN3
Ensembl: ENSG00000164744
Chromosome: 7
Canonical length: 357 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Predicted to enable protein-membrane adaptor activity. Predicted to be located in nuclear inner membrane. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in nuclear envelope. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

357 residues, UniProt reviewed canonical sequence.

>Q8TAQ9|SUN3
     1  MSGKTKARRA AMFFRRCSED ASGSASGNAL LSEDENPDAN GVTRSWKIIL STMLTLTFLL
    61  VGLLNHQWLK ETDVPQKSRQ LYAIIAEYGS RLYKYQARLR MPKEQLELLK KESQNLENNF
   121  RQILFLIEQI DVLKALLRDM KDGMDNNHNW NTHGDPVEDP DHTEEVSNLV NYVLKKLRED
   181  QVEMADYALK SAGASIIEAG TSESYKNNKA KLYWHGIGFL NHEMPPDIIL QPDVYPGKCW
   241  AFPGSQGHTL IKLATKIIPT AVTMEHISEK VSPSGNISSA PKEFSVYGIT KKCEGEEIFL
   301  GQFIYNKTGT TVQTFELQHA VSEYLLCVKL NIFSNWGHPK YTCLYRFRVH GTPGKHI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

testis: 39 nTPM
basal ganglia: 0.1 nTPM
cerebral cortex: 0.1 nTPM
epididymis: 0.1 nTPM
hypothalamus: 0.1 nTPM
thyroid gland: 0.1 nTPM

Single-cell type

early spermatids: 735 nCPM
late primary spermatocytes: 322 nCPM
late spermatids: 92 nCPM
extravillous trophoblasts: 68 nCPM
migrating cytotrophoblasts: 15 nCPM
early primary spermatocytes: 12 nCPM

Immune cell

basophil: 0.2 nTPM
gdT-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
NK-cell: 0.1 nTPM

Brain region

basal ganglia: 0.6 nTPM
cerebral cortex: 0.6 nTPM
cerebellum: 0.5 nTPM
medulla oblongata: 0.5 nTPM
pons: 0.5 nTPM
white matter: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: 0.52
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

protein-membrane adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SUN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUN3 as an antibody target. Whether an autoantibody or antibody against SUN3 could matter depends on whether native SUN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SUN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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