SUN5
SUN domain-containing protein 5
Also known as: dJ726C3.1, SPAG4L, SUN5_HUMAN, TSARG4
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8TC36
- Gene
- SUN5
- Ensembl
- ENSG00000167098
- Chromosome
- 20
- Canonical length
- 379 aa
- Protein class
- Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
- Quaternary structure
- Homotrimer
OverviewNCBI Gene
The protein encoded by this gene appears to play a role in the meiotic stage of spermatogenesis. The encoded protein localizes to the junction between the sperm head and body and may be involved in nuclear envelope reconstitution and nuclear migration. Mutations in this gene have been implicated in acephalic spermatozoa syndrome. [provided by RefSeq, May 2017]
Canonical amino-acid sequenceUniProt
379 residues, UniProt reviewed canonical sequence.
>Q8TC36|SUN5
1 MPRSSRSPGD PGALLEDVAH NPRPRRIAQR GRNTSRMAED TSPNMNDNIL LPVRNNDQAL
61 GLTQCMLGCV SWFTCFACSL RTQAQQVLFN TCRCKLLCQK LMEKTGILLL CAFGFWMFSI
121 HLPSKMKVWQ DDSINGPLQS LRLYQEKVRH HSGEIQDLRG SMNQLIAKLQ EMEAMSDEQK
181 MAQKIMKMIH GDYIEKPDFA LKSIGASIDF EHTSVTYNHE KAHSYWNWIQ LWNYAQPPDV
241 ILEPNVTPGN CWAFEGDRGQ VTIQLAQKVY LSNLTLQHIP KTISLSGSLD TAPKDFVIYG
301 MEGSPKEEVF LGAFQFQPEN IIQMFPLQNQ PARAFSAVKV KISSNWGNPG FTCLYRVRVH
361 GSVAPPREQP HQNPYPKRDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SUN5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.45
- Highest tissue expression
- 43 nTPM
Expression across tissuesHPA
Tissue
- testis: 43 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- early spermatids: 780 nCPM
- late primary spermatocytes: 191 nCPM
- late spermatids: 75 nCPM
- sertoli cells: 3.7 nCPM
- leydig cells: 1.4 nCPM
- retinal amacrine cells: 1.1 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about SUN5.
Disease | AllUniProt
Conditions SUN5 is implicated in, by any mechanism.
- Spermatogenic failure 16 (SPGF16) MIM:617187
Disease | GeneticClinVar
8 pathogenic / likely-pathogenic of 69 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- Spermatogenic failure 16
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.25
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.69
- DepMap mean gene effect
- -0.16
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SUN5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SUN5 as an antibody target. Whether an autoantibody or antibody against SUN5 could matter depends on whether native SUN5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SUN5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SUN5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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