Seroatlas · Human Serome Atlas

OVOS1

Ovostatin homolog 1

Also known as: OVOS1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6IE37
Gene: OVOS1
Canonical length: 1185 aa
Quaternary structure: Homotetramer

OverviewNCBI Gene

No narrative summary is available for OVOS1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1185 residues, UniProt reviewed canonical sequence.

>Q6IE37|OVOS1
     1  MHVHVCVCLC VCIYTSSCVC ACVHMCMRDA LLAEGRGGGL AAADDFLYLE CCKCFSQESQ
    61  IAMVCQERSQ NETYEVKMNN DTEACRATLN LEERRSVAIR SRENVVFVQT DKPTYKPGQK
   121  DVNGIAQFFL DTYTFTYPNI TLKDPQNNRI FQRQNVTSFR NITQLSFQLI SEPMFGDYWI
   181  VVKRNSRETV THQFAVKRYV LPKFEVTVNA PQTVTISDDE FQVDVCAYNF GQPVQGETQI
   241  RVCREYFSSS NCEKNENEIC EQFIAQVQTN LDIFTLLCSS FLTVMQISEK TSVFITQLLG
   301  TVNFENMDTF YRRGISYFGQ LKFSDPNNVP MVNKLLQLEL NDEFIGNYTT DENGEAQFSI
   361  DTSDIFDPEF NLKVRHQRTE ECYLPSWLTP QYLDAHFLVS RFYSRTNSFL KIVPEPKQLE
   421  CNQQKVVTVH YSLNSEAYED DSNVKFFYLN GNFSFPISIS ADLAPAAVLF VYTLHPSGEI
   481  VADSVRFQVD KCFKHKVNIK FSNEQGLPGS NASLCLQAAP VLFCALRAVD RNVLLLKSEQ
   541  QLSAESVSSL YNMVPSIEPY GYFYHGLNLD DGKEDPCIPQ RDMFYNGLYY TPVSNYGDGD
   601  IYNIVRVRSL RILENIIQTV RTNFPETWMW DLVSVSSSGS ANLSFLIPDT ITQWEASGFC
   661  VNGDVGFGIS STTTLEVSQP FFIEIASPFS VVQNEQFDLI VNVFSYRNTC VEVSYIWECL
   721  PGKVNITVVA ESKQSSACPN EGMEQQKLNW KDTVVQSFLV EFLFLGDILG LALQNLVVLQ
   781  MPYGSGEQNA ALLASDTYVL DYLKSTEQLT EEVQSKAFFL SILGYQRQLS FKNSDGSYSV
   841  FWQQSQKGSI WLSALTFKTL ERMKKYVFID ENVQKQTLIW LSSQQKTSGC FKNDGQLFNH
   901  ALRNALFCLE AALDSGVTNG YNHAILAYAF ALAGKEKQVE SLLQTLDQSA PKLSKRYYWE
   961  RERKPKTEEF PSFIPWAPSA QTEKSCYVLL AVISRKIPDL TYASKIVQWL AQRMNSHGGF
  1021  SSNQVINVGL ILIAARGEEG LFSKDQNTVT FSSEGSSEIF QVNGHNRLLV QRSEVTQAPG
  1081  EYTVDVEGHG CTFIQIFRYT GIRNKSSMVV IDVKMLSGFT PTMSSIEEVN NRSLIFQHKD
  1141  SYIEYKRADS FPFSVEQSNL VFNIQPAPAM VYDYYEKGRQ ATAMP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OVOS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about OVOS1.

Disease | ImmuneIEDB

Conditions an epitope on OVOS1 was assayed in.

human immunodeficiency virus infectious disease T cell

OntologyGO

Molecular functions

serine-type endopeptidase inhibitor activity

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OVOS1 as an antibody target. Whether an autoantibody or antibody against OVOS1 could matter depends on whether native OVOS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OVOS1 is annotated as secreted, so native OVOS1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label OVOS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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