Seroatlas · Human Serome Atlas

LEMD1

LEM domain-containing protein 1

Also known as: CT50, LEMD1_HUMAN, LEMP-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68G75
Gene: LEMD1
Ensembl: ENSG00000186007
Chromosome: 1
Canonical length: 181 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

181 residues, UniProt reviewed canonical sequence.

>Q68G75|LEMD1
     1  MVDVKCLSDC KLQNQLEKLG FSPGPILPST RKLYEKKLVQ LLVSPPCAPP VMNGPRELDG
    61  AQDSDDSEEL NIILQGNIIL STEKSKKLKK WPEASTTKRK AVDTYCLDYK PSKGRRWAAR
   121  APSTRITYGT ITKERDYCAE DQTIESWREE GFPVGLKLAV LGIFIIVVFV YLTVENKSLF
   181  G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LEMD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

testis: 53 nTPM
epididymis: 14 nTPM
cerebellum: 3.5 nTPM
salivary gland: 1.8 nTPM
fallopian tube: 1.5 nTPM
retina: 1.3 nTPM

Single-cell type

late spermatids: 6,871 nCPM
early spermatids: 1,205 nCPM
late primary spermatocytes: 219 nCPM
retinal bipolar cells: 57 nCPM
cone photoreceptor cells: 41 nCPM
renal collecting duct principal cells: 37 nCPM

Immune cell

NK-cell: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

pons: 6.3 nTPM
cerebellum: 5.8 nTPM
thalamus: 4.9 nTPM
medulla oblongata: 3.4 nTPM
midbrain: 2.7 nTPM
cerebral cortex: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0
gnomAD missense Z: 0.04
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LEMD1 as an antibody target. Whether an autoantibody or antibody against LEMD1 could matter depends on whether native LEMD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LEMD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LEMD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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