Seroatlas · Human Serome Atlas

ERMN

Ermin

Also known as: ERMIN, ERMIN_HUMAN, JN, KIAA1189

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAM6
Gene: ERMN
Ensembl: ENSG00000136541
Chromosome: 2
Canonical length: 284 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable actin filament binding activity. Involved in actin filament organization; regulation of cell projection organization; and regulation of cell shape. Located in cell cortex; internode region of axon; and paranode region of axon. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

284 residues, UniProt reviewed canonical sequence.

>Q8TAM6|ERMN
     1  MTDVPATFTQ AECNGDKPPE NGQQTITKIS EELTDVDSPL PHYRVEPSLE GALTKGSQEE
    61  RRKLQGNMLL NSSMEDKMLK ENPEEKLFIV HKAITDLSLQ ETSADEMTFR EGHQWEKIPL
   121  SGSNQEIRRQ KERITEQPLK EEEDEDRKNK GHQAAEIEWL GFRKPSQADM LHSKHDEEQK
   181  VWDEEIDDDD DDNCNNDEDE VRVIEFKKKH EEVSQFKEEG DASEDSPLSS ASSQAVTPDE
   241  QPTLGKKSDI SRNAYSRYNT ISYRKIRKGN TKQRIDEFES MMHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERMN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 596 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 596 nTPM
midbrain: 301 nTPM
hippocampal formation: 214 nTPM
amygdala: 153 nTPM
basal ganglia: 152 nTPM
cerebral cortex: 131 nTPM

Single-cell type

retinal pigment epithelial cells: 716 nCPM
oligodendrocytes: 274 nCPM
choroid plexus epithelial cells: 17 nCPM
neutrophils: 12 nCPM
microglia: 11 nCPM
lacrimal acinar cells: 7.2 nCPM

Immune cell

basophil: 1 nTPM
neutrophil: 0.8 nTPM
NK-cell: 0.6 nTPM
gdT-cell: 0.5 nTPM
naive B-cell: 0.4 nTPM
naive CD8 T-cell: 0.4 nTPM

Brain region

white matter: 810 nTPM
medulla oblongata: 648 nTPM
basal ganglia: 495 nTPM
pons: 484 nTPM
cerebellum: 446 nTPM
midbrain: 444 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
gnomAD missense Z: -0.16
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

actin filament binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERMN as an antibody target. Whether an autoantibody or antibody against ERMN could matter depends on whether native ERMN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERMN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERMN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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