Hypoxia induced protein, domain

Definition

This entry represents the transmembrane region found in the hypoxia induced gene 1 (HIG1), Respiratory supercomplex factor 1/2 (rcf1) and other proteins such as RING-H2 finger protein ATL48. The hypoxia induced gene 1 (HIG1) or hypoglycemia/hypoxia inducible mitochondrial protein (HIMP1) is up-regulated by stresses of the microenvironment such as low oxygen or low glucose conditions. HIG1 is a mitochondrial inner membrane protein, which is ubiquitously expressed. It is predicted to be an integral membrane protein consisting of two hydrophobic helices, 21-23 residues in length that might tend to form a hairpin-like loop across the bilayer. HIG1 could be implied in apoptotic or cytoprotective signals. HIG1 is a member of a well conserved eukaryote protein family. The predicted transmembrane helice (TMH) and loop regions represent the most highly conserved regions in these proteins [[cite:PMID:15968589], [cite:PMID:16815968]]. The profile we developed covers the predicted TMH and loop regions. This domain is found in proteins thought to be involved in the response to hypoxia PMID:11172064. It is also found in altered inheritance of mitochondria proteins.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• HIGD1A
• HIGD1B
• HIGD1C
• HIGD2A
• HIGD2B