HIGD1C
HIG1 domain family member 1C
Also known as: Gm921, HIG1C_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A8MV81
- Gene
- HIGD1C
- Ensembl
- ENSG00000214511
- Chromosome
- 12
- Canonical length
- 97 aa
- Protein class
- Predicted membrane proteins
OverviewNCBI Gene
Predicted to be involved in mitochondrial respirasome assembly. Predicted to act upstream of or within response to hypoxia. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
97 residues, UniProt reviewed canonical sequence.
>A8MV81|HIGD1C
1 MSSDNQWSAD EDEGQLSRLI RKSRDSPFVP IGIAGFVTVV SCGLYKLKYR RDQKMSIHLI
61 HMRVAAQGFV VGAVTLGVLY SMYKDYIRPR FFSESKKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HIGD1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 2
- Mean surface accessibility (rSASA)
- 0.52
- Highest tissue expression
- 0.8 nTPM
Expression across tissuesHPA
Tissue
- pancreas: 0.8 nTPM
- liver: 0.6 nTPM
- skeletal muscle: 0.4 nTPM
- stomach: 0.4 nTPM
- thyroid gland: 0.4 nTPM
- adipose tissue: 0.3 nTPM
Single-cell type
- microglia: 7.2 nCPM
- bergmann glia: 6.1 nCPM
- oligodendrocyte progenitor cells: 6 nCPM
- oligodendrocytes: 4.9 nCPM
- astrocytes: 4 nCPM
- brain excitatory neurons: 3.8 nCPM
Immune cell
- myeloid DC: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- cerebellum: 6.9 nTPM
- white matter: 6.4 nTPM
- cerebral cortex: 5 nTPM
- choroid plexus: 4.6 nTPM
- midbrain: 4.5 nTPM
- basal ganglia: 4.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.81
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.03
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HIGD1C as an antibody target. Whether an autoantibody or antibody against HIGD1C could matter depends on whether native HIGD1C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HIGD1C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HIGD1C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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