HIGD1B
HIG1 domain family member 1B
Also known as: CLST11240, CLST11240-15, HIG1B_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9P298
- Gene
- HIGD1B
- Ensembl
- ENSG00000131097
- Chromosome
- 17
- Canonical length
- 99 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Microtubules,Cytokinetic bridge,Mitotic spindle
OverviewNCBI Gene
This gene encodes a member of the hypoxia inducible gene 1 (HIG1) domain family. The encoded protein is localized to the cell membrane and has been linked to tumorigenesis and the progression of pituitary adenomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Canonical amino-acid sequenceUniProt
99 residues, UniProt reviewed canonical sequence.
>Q9P298|HIGD1B
1 MSANRRWWVP PDDEDCVSEK LLRKTRESPL VPIGLGGCLV VAAYRIYRLR SRGSTKMSIH
61 LIHTRVAAQA CAVGAIMLGA VYTMYSDYVK RMAQDAGEKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HIGD1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 2
- Mean surface accessibility (rSASA)
- 0.52
- Highest tissue expression
- 98 nTPM
Expression across tissuesHPA
Tissue
- placenta: 98 nTPM
- basal ganglia: 49 nTPM
- heart muscle: 45 nTPM
- midbrain: 40 nTPM
- lung: 37 nTPM
- amygdala: 33 nTPM
Single-cell type
- pericytes: 341 nCPM
- vascular smooth muscle cells: 69 nCPM
- hepatic stellate cells: 13 nCPM
- vascular endothelial cells: 11 nCPM
- extravillous trophoblasts: 10 nCPM
- retinal horizontal cells: 8 nCPM
Immune cell
- basophil: 1.7 nTPM
- gdT-cell: 1.2 nTPM
- myeloid DC: 1.2 nTPM
- intermediate monocyte: 1 nTPM
- memory CD8 T-cell: 0.9 nTPM
- naive CD4 T-cell: 0.9 nTPM
Brain region
- thalamus: 18 nTPM
- pons: 17 nTPM
- hypothalamus: 15 nTPM
- medulla oblongata: 15 nTPM
- amygdala: 14 nTPM
- basal ganglia: 14 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.89
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.22
- DepMap mean gene effect
- -0.15
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HIGD1B as an antibody target. Whether an autoantibody or antibody against HIGD1B could matter depends on whether native HIGD1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HIGD1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HIGD1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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