Seroatlas · Human Serome Atlas

HIGD2B

HIG1 domain family member 2B

Also known as: HIG2B_HUMAN, HIGD2BP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q4VC39
Gene
HIGD2B
Ensembl
ENSG00000175202
Chromosome
15
Canonical length
106 aa
Protein class
Predicted membrane proteins
Subcellular location
Mitochondria,Cytosol

OverviewNCBI Gene

Predicted to be involved in mitochondrial respirasome assembly. Predicted to be located in membrane. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

106 residues, UniProt reviewed canonical sequence.

>Q4VC39|HIGD2B
     1  MATLGFVTPE APFESSKPPI FEGLSPTVYS NPEGFKEKFL RKTRENPVVP IGFLCTAAVL
    61  TNGLYCFHQG NSQCSRLMMH TQIAAQGFTI AAILLGLAAT AMKSPP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HIGD2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
3.4 nTPM

Expression across tissuesHPA

Tissue

  • testis: 3.4 nTPM
  • epididymis: 0.3 nTPM
  • thyroid gland: 0.2 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM

Single-cell type

  • late primary spermatocytes: 41 nCPM
  • early spermatids: 14 nCPM
  • late spermatids: 13 nCPM
  • early primary spermatocytes: 11 nCPM
  • epididymal principal cells: 1.5 nCPM
  • breast lactating cells: 1.3 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 0.2 nTPM
  • cerebral cortex: 0.2 nTPM
  • pons: 0.2 nTPM
  • white matter: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • cerebellum: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
0.22

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HIGD2B as an antibody target. Whether an autoantibody or antibody against HIGD2B could matter depends on whether native HIGD2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HIGD2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HIGD2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HIGD2B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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