Seroatlas · Human Serome Atlas

HIGD1A

HIG1 domain family member 1A, mitochondrial

Also known as: DKFZP564K247, HIG1, HIG1A_HUMAN, RCF1A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y241
Gene: HIGD1A
Ensembl: ENSG00000181061
Chromosome: 3
Canonical length: 93 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Acts upstream of or within negative regulation of apoptotic process. Located in mitochondrion and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

93 residues, UniProt reviewed canonical sequence.

>Q9Y241|HIGD1A
     1  MSTDTGVSLP SYEEDQGSKL IRKAKEAPFV PVGIAGFAAI VAYGLYKLKS RGNTKMSIHL
    61  IHMRVAAQGF VVGAMTVGMG YSMYREFWAK PKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HIGD1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 321 nTPM

Expression across tissuesHPA

Tissue

liver: 321 nTPM
heart muscle: 303 nTPM
tongue: 296 nTPM
rectum: 282 nTPM
colon: 277 nTPM
spinal cord: 275 nTPM

Single-cell type

parietal cells: 64 nCPM
hepatocytes: 37 nCPM
colonocytes: 15 nCPM
gastric chief cells: 13 nCPM
hepatic stellate cells: 13 nCPM
foveolar cells: 9.7 nCPM

Immune cell

plasmacytoid DC: 510 nTPM
total PBMC: 171 nTPM
non-classical monocyte: 144 nTPM
eosinophil: 131 nTPM
basophil: 117 nTPM
intermediate monocyte: 116 nTPM

Brain region

white matter: 167 nTPM
spinal cord: 129 nTPM
hypothalamus: 127 nTPM
pons: 123 nTPM
cerebellum: 119 nTPM
midbrain: 116 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.26
gnomAD pLI: 0.03
gnomAD missense Z: 0.15
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HIGD1A as an antibody target. Whether an autoantibody or antibody against HIGD1A could matter depends on whether native HIGD1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HIGD1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HIGD1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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